Symmetry of fMRI activation in the primary sensorimotor cortex during unilateral chewing
Symmetry of fMRI activation in the primary sensorimotor cortex during unilateral chewing
复制标题
单侧咀嚼过程中初级感觉运动皮层功能磁共振成像激活的对称性
DOI：
10.1007/s00784-016-1858-4
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发表时间：
2017
影响因子：
3.4
通讯作者：
Kordass B.
中科院分区：
文献类型：
--
作者：
Lotze M;Domin M;Kordass B.
目的功能磁共振成像（fMRI）是一种最先进的技术，可以分析大脑对口腔系统许多行为方面的影响，如咀嚼和咀嚼。对大脑咀嚼表征的成像研究表明，在单侧咀嚼过程中，皮层偏侧化的差异结果。我们研究的目的是阐明在单侧咀嚼时大脑反应的影响。材料与方法应用功能磁共振成像（fMRI）比较了15名健康受试者在自然牙中心咬合和咀嚼位于左右牙的牙龈时的脑活动。组数据通过Talairach归一化进行处理，另外通过对单个解剖标志的激活最大值进行分配，以避免归一化过程中激活位点的空间精确性的可能损失。结果Talairach归一化组数据显示，双侧初级（S1）和次级（S2）体感觉皮质、初级运动（M1）和运动前皮质、辅助运动区（SMA）和内侧扣带回、双侧小脑前半球和蚓部、脑岛、眶额皮质、丘脑和左侧白脑是咬合运动的表征部位。右侧咀嚼与左侧咀嚼的激活没有差异，两者都显示了双侧咬合相关区域的激活。两种方法，基于群体归一化的方法和基于个体评估的方法，在初级运动皮层、初级和次级体感皮层以及小脑前部的最大激活位置上都显示出显著的低差异。所有测试的咀嚼运动都涉及双侧感觉运动激活，而激活强度没有显著的侧化。结论总的来说，目前的研究还不能证实咬合运动向优势侧的普遍偏侧。用牙齿的左侧或右侧咀嚼对大脑咀嚼的表征没有影响。临床相关性研究结果描述了咀嚼和咀嚼的脑效应评估的基本效果。基于这些结果，临床功能磁共振成像研究可以在不同的患者组中进行。
ObjectiveFunctional magnetic resonance imaging (fMRI) is one of the most advanced techniques to analyze the cerebral effects on many behavior aspects of the oral system such as chewing and mastication. Studies on imaging of the cerebral representation of chewing demonstrated differential results with respect to cortical lateralization during unilateral chewing. The aim of our study is to clarify the effects of cerebral responses during unilateral chewing.Material and methodsWe used fMRI to compare brain activities during occlusal function in centric occlusion on natural teeth and chewing on a gum located on the right or the left teeth in 15 healthy subjects. Group data were performed by Talairach normalization and in addition by an assignment of activation maxima to individual anatomical landmarks in order to avoid possible loss of spatial preciseness of activation sites by normalization procedures.ResultsEvaluation of group data by Talairach normalization revealed representation sites for occlusal movements in bilateral primary (S1) and secondary (S2) somatosensory cortices, primary motor (M1) and premotor cortices, supplementary motor area (SMA) and medial cingulate gyrus, bilateral anterior cerebellar hemispheres and vermis, insula, orbitofrontal cortex, thalamus, and left pallidum. Right-sided chewing showed no differential activation to left-sided chewing, and both showed activation in areas also involved in bilateral occlusion. Both techniques, the one based on group normalization and the one based on an individual evaluation method, revealed remarkable low differences in activation maximum location in the primary motor, the primary and secondary somatosensory cortices, and the anterior cerebellar lobe. All chewing movements tested involved bilateral sensorimotor activation without a significant lateralization of activation intensities.ConclusionOverall, a general lateralization of occlusion movements to the dominant side could not be verified in the present study. Chewing on the left or on the right side of teeth makes no difference for brain representation of chewing.Clinical relevanceThe results describe the basic effects of what we can expect by evaluation of cerebral effects of chewing and mastication. Based on these results, clinical fMRI studies can be performed in different patient groups.
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影响因子：
3.3
作者：
T. Takahashi;T. Miyamoto;Atsushi Terao;A. Yokoyama
通讯作者：
T. Takahashi;T. Miyamoto;Atsushi Terao;A. Yokoyama
影响因子：
3.4
作者：
Doyon, J;Owen, AM;Evans, AC
通讯作者：
Evans, AC
影响因子：
5.7
作者：
Eickhoff, SB;Stephan, KE;Zilles, K
通讯作者：
Zilles, K
功能磁共振成像 (fMRI) 区分闭塞和吞咽的大脑表征
DOI：
10.1152/ajpgi.00456.2012
发表时间：
2013
期刊：
American journal of physiology. Gastrointestinal and liver physiology
影响因子：
--
作者：
Mihai PG;von Bohlen;Halbach O;Lotze M.
通讯作者：
Lotze M.