Modulatory interactions between the default mode network and task positive networks in resting-state.
Modulatory interactions between the default mode network and task positive networks in resting-state.
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作者：
Di X;Biswal BB
两个主要的大脑网络，即，默认模式网络（DMN）和任务正网络在静息状态下通常显示负的和可变的连通性。在本研究中，我们研究是否DMN和任务的积极网络的不同组成部分之间的连接调制的其他脑区，通过使用生理生理相互作用（PPI）的静息状态功能磁共振成像数据。首先进行空间独立成分分析，以确定代表感兴趣的网络，包括前和后DMN，显着性，背注意，左和右执行网络的组件。在这些网络对之间进行PPI分析，以识别与两个网络显示调节相互作用的网络或区域。网络和体素分析显示，DMN，显着性和执行网络之间的相互积极的调节作用。结合显著性网络区域的解剖学特性，研究结果表明，显著性网络可能调节DMN和执行网络之间的关系。此外，体素分析表明，基底神经节和丘脑与显著性网络和背侧注意网络正向相互作用，与显著性网络和DMN负向相互作用。结果表明，DMNs和任务的积极网络之间的复杂的调制相互作用在休息状态，并建议这些网络之间的通信可能是由一些关键的大脑结构，如显着性网络，基底神经节，丘脑调制。
The two major brain networks, i.e., the default mode network (DMN) and the task positive network, typically reveal negative and variable connectivity in resting-state. In the present study, we examined whether the connectivity between the DMN and different components of the task positive network were modulated by other brain regions by using physiophysiological interaction (PPI) on resting-state functional magnetic resonance imaging data. Spatial independent component analysis was first conducted to identify components that represented networks of interest, including the anterior and posterior DMNs, salience, dorsal attention, left and right executive networks. PPI analysis was conducted between pairs of these networks to identify networks or regions that showed modulatory interactions with the two networks. Both network-wise and voxel-wise analyses revealed reciprocal positive modulatory interactions between the DMN, salience, and executive networks. Together with the anatomical properties of the salience network regions, the results suggest that the salience network may modulate the relationship between the DMN and executive networks. In addition, voxel-wise analysis demonstrated that the basal ganglia and thalamus positively interacted with the salience network and the dorsal attention network, and negatively interacted with the salience network and the DMN. The results demonstrated complex modulatory interactions among the DMNs and task positive networks in resting-state, and suggested that communications between these networks may be modulated by some critical brain structures such as the salience network, basal ganglia, and thalamus.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.1
作者：
Di, Xin;Biswal, Bharat B.
通讯作者：
Biswal, Bharat B.
影响因子：
5.7
作者：
Di X;Biswal BB
通讯作者：
Biswal BB
影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM