Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion.
Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion.
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DOI：
10.1111/jvim.14829
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发表时间：
2017-11
影响因子：
2.6
通讯作者：
Early PJ
中科院分区：
文献类型：
--
作者：
Castel A;Olby NJ;Mariani CL;Muñana KR;Early PJ
进行性骨髓瘤（PMM）是一种与急性椎间盘突出症（IVDE）相关的灾难性疾病。已发表的有关该病临床特征的资料有限。描述一个大型病例队列中PMM临床症状的发生和进展。51只狗，18只组织病理学证实为PMM， 33只根据临床体征和诊断影像学推定诊断。回顾性研究。通过病历检索确定IVDE和组织病理学诊断为PMM或临床高度怀疑的犬。提取体征的性质和进展数据。51只狗中有24只是腊肠犬。T12-T13是椎间盘突出最常见的部位（56例中有12例），55例中至尾侧腰椎间盘（L3和L6之间）中有18例受到影响。PMM症状的发作范围从首次评估时（17/51）到就诊后5天，51例中有25例在48小时内出现症状。从PMM发病到安乐死或死亡的体征进展，不包括7例出现时被安乐死的病例，从1到13天不等，其中23例在3天内被安乐死。51只狗中有30只记录了非特异性全身体征。大多数狗在出现后2天内出现PMM，并在另外3天内被安乐死。然而，发病可延迟至5天后，进展到安乐死需要长达2周。中至尾侧腰椎间盘可能与PMM的风险增加有关。
Progressive myelomalacia (PMM) is a catastrophic disease associated with acute intervertebral disc extrusion (IVDE). Published data on the clinical characteristics of this disease are limited. To describe the onset and progression of clinical signs of PMM in a large case cohort. Fifty‐one dogs, 18 with histopathologically confirmed PMM, 33 presumptively diagnosed based on clinical signs and diagnostic imaging. Retrospective study. Dogs with confirmed IVDE and either a histopathologic diagnosis of PMM or a high clinical suspicion were identified by medical record search. Data on nature and progression of signs were extracted. Twenty‐four of 51 dogs were Dachshunds. T12–T13 was the most common site of disc extrusion (12 of 56), and 18 of 55 of mid‐to‐caudal lumbar discs (between L3 and L6) were affected. Onset of PMM signs ranged from present at first evaluation (17/51) to 5 days after presentation, with 25 of 51 cases developing signs within 48 hours. Progression of signs from onset of PMM to euthanasia or death, excluding 7 cases euthanized at presentation, ranged from 1 to 13 days with 23 being euthanized within 3 days. Nonspecific systemic signs were documented in 30 of 51 dogs. The majority of dogs developed PMM within 2 days of presentation and was euthanized within another 3 days. However, onset can be delayed up to 5 days after presentation with progression to euthanasia taking as long as 2 weeks. Mid‐to‐caudal lumbar discs might be associated with an increased risk of PMM.
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影响因子：
--
作者：
Mitchell, Thomas J;Knowler, Susan P;Rusbridge, Clare
通讯作者：
Rusbridge, Clare
影响因子：
2.6
作者：
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通讯作者：
Volk, Holger A.
影响因子：
1
作者：
Marino, Dominic J.;Loughin, Catherine A.;Akerman, Meredith B.
通讯作者：
Akerman, Meredith B.
DOI：
10.5326/15473317-36-1-34
发表时间：
2000-01-01
影响因子：
1.3
作者：
Rusbridge, C;MacSweeny, JE;Wheeler, SJ
通讯作者：
Wheeler, SJ
影响因子：
2.6
作者：
Garosi, L;McConnell, JF;Schatzberg, SJ
通讯作者：
Schatzberg, SJ