Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008-2010.
Estimated life expectancy in a Scottish cohort with type 1 diabetes, 2008-2010.
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与1型糖尿病的苏格兰队列中估计预期寿命，2008- 2010年。
DOI：
10.1001/jama.2014.16425
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发表时间：
2015-01-06
影响因子：
120.7
通讯作者：
Colhoun, Helen M.
中科院分区：
文献类型：
--
作者：
Livingstone, Shona J.;Levin, Daniel;Looker, Helen C.;Lindsay, Robert S.;Wild, Sarah H.;Joss, Nicola;Leese, Graham;Leslie, Peter;McCrimmon, Rory J.;Metcalfe, Wendy;McKnight, John A.;Morris, Andrew D.;Pearson, Donald W. M.;Petrie, John R.;Philip, Sam;Sattar, Naveed A.;Traynor, Jamie P.;Colhoun, Helen M.
1型糖尿病在历史上与预期寿命的显着减少有关。1型糖尿病的治疗在过去30年中取得了重大进展。需要对1型糖尿病对预期寿命的影响进行当代估计。研究苏格兰1型糖尿病患者和非1型糖尿病患者目前的预期寿命。我们还研究了1型糖尿病患者预期寿命的任何损失是否仅限于那些患有肾脏疾病的患者。前瞻性队列研究：2008年至2010年在苏格兰存活的所有1型糖尿病患者，年龄≥ 20岁，并在全国范围内登记（n=24 691，贡献67 712人年和1043例死亡）。1型糖尿病患者和非1型糖尿病患者之间的预期寿命差异以及各种原因导致的差异百分比。在达到20岁时，1型糖尿病男性的预期寿命增加了46.2年，而非1型糖尿病男性的预期寿命增加了57.3年，估计糖尿病患者的预期寿命减少了11.1年（95% CI，10.1-12.1）。从20岁起，1型糖尿病女性的预期寿命增加了48.1岁，未患1型糖尿病女性的预期寿命增加了61.0岁，估计糖尿病患者的预期寿命减少了12.9岁（95% CI，11.7-14.1）。即使在估计肾小球滤过率为90 mL/min/1.73m2或更高的1型糖尿病患者中，预期寿命也会缩短（男性49.0岁，女性53.1岁），估计从20岁开始损失8.3年（95% CI，6.5-10.1）男性和7.9年（95% CI，5.5-10.3）女性。总体而言，估计预期寿命损失的最大百分比与缺血性心脏病有关（男性36%，女性31%），但糖尿病昏迷或酮症酸中毒死亡与50岁之前发生的估计损失的最大百分比相关（男性29.4%，女性21.7%）。根据2008年至2010年的数据，苏格兰1型糖尿病患者的预期寿命估计值表明，与无1型糖尿病的一般人群相比，20岁时男性预期寿命估计损失约11年，女性约13年。
Type 1 diabetes has historically been associated with a significant reduction in life expectancy. Major advances in treatment of type 1 diabetes have occurred in the past 3 decades. Contemporary estimates of the effect of type 1 diabetes on life expectancy are needed. To examine current life expectancy in people with and without type 1 diabetes in Scotland. We also examined whether any loss of life expectancy in patients with type 1 diabetes is confined to those who develop kidney disease. Prospective cohort of all individuals alive in Scotland with type 1 diabetes who were aged 20 years or older from 2008 through 2010 and were in a nationwide register (n=24 691 contributing 67 712 person-years and 1043 deaths). Differences in life expectancy between those with and those without type 1 diabetes and the percentage of the difference due to various causes. Life expectancy at an attained age of 20 years was an additional 46.2 years among men with type 1 diabetes and 57.3 years among men without it, an estimated loss in life expectancy with diabetes of 11.1 years (95% CI, 10.1-12.1). Life expectancy from age 20 years was an additional 48.1 years among women with type 1 diabetes and 61.0 years among women without it, an estimated loss with diabetes of 12.9 years (95% CI, 11.7-14.1). Even among those with type 1 diabetes with an estimated glomerular filtration rate of 90 mL/min/1.73m2 or higher, life expectancy was reduced (49.0 years in men, 53.1 years in women) giving an estimated loss from age 20 years of 8.3 years (95% CI, 6.5-10.1) for men and 7.9 years (95% CI, 5.5-10.3) for women. Overall, the largest percentage of the estimated loss in life expectancy was related to ischemic heart disease (36% in men, 31% in women) but death from diabetic coma or ketoacidosis was associated with the largest percentage of the estimated loss occurring before age 50 years (29.4% in men, 21.7% in women). Estimated life expectancy for patients with type 1 diabetes in Scotland based on data from 2008 through 2010 indicated an estimated loss of life expectancy at age 20 years of approximately 11 years for men and 13 years for women compared with the general population without type 1 diabetes.
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影响因子：
16.2
作者：
Brown, LJ;Scott, RS;Moir, CL
通讯作者：
Moir, CL
影响因子：
8.2
作者：
Jorgensen, Marit E.;Almdal, Thomas P.;Carstensen, Bendix
通讯作者：
Carstensen, Bendix
影响因子：
16.2
作者：
de Ferranti SD;de Boer IH;Fonseca V;Fox CS;Golden SH;Lavie CJ;Magge SN;Marx N;McGuire DK;Orchard TJ;Zinman B;Eckel RH
通讯作者：
Eckel RH
影响因子：
7.7
作者：
Groop PH;Thomas MC;Moran JL;Wadèn J;Thorn LM;Mäkinen VP;Rosengård-Bärlund M;Saraheimo M;Hietala K;Heikkilä O;Forsblom C;FinnDiane Study Group
通讯作者：
FinnDiane Study Group
影响因子：
7.7
作者：
Miller RG;Secrest AM;Sharma RK;Songer TJ;Orchard TJ
通讯作者：
Orchard TJ