Improvements in the life expectancy of type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications study cohort.
Improvements in the life expectancy of type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications study cohort.
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DOI：
10.2337/db11-1625
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发表时间：
2012-11
期刊：
影响因子：
7.7
通讯作者：
Orchard TJ
中科院分区：
文献类型：
--
作者：
Miller RG;Secrest AM;Sharma RK;Songer TJ;Orchard TJ
1型糖尿病患者的生存率有所改善，但对美国1型糖尿病人群预期寿命的影响尚未得到很好的确定。我们的目的是估计匹兹堡糖尿病并发症流行病学（EDC）研究队列的预期寿命，并通过比较基于糖尿病诊断年份的两个亚队列（1950-1964 [n = 390] vs. 1965-1980 [n = 543]）来量化改善。EDC研究是一项前瞻性队列研究，纳入了1950年至1980年在匹兹堡儿童医院诊断的933名儿童期发病（年龄<17岁）1型糖尿病患者。死亡率确定于2009年12月31日删失。编制了简化队列寿命表以计算预期寿命。1950-1964年的子队列中有237人（60.8%）死亡，而1965-1980年的子队列中有88人（16.2%）死亡。1965-1980年诊断的受试者的出生时预期寿命比1950-1964年诊断的受试者高1.15岁（分别为68.8 [95% CI 64.7-72.8] vs. 53.4 [50.8-56.0]岁）（P < 0.0001）;无论性别或诊断时的青春期状态如何，这种差异都持续存在。预期寿命的改善强调了保险公司需要更新对儿童期发病的1型糖尿病患者预期寿命的分析，因为保险费的加权是基于过时的估计。
Survival in type 1 diabetes has improved, but the impact on life expectancy in the U.S. type 1 diabetes population is not well established. Our objective was to estimate the life expectancy of the Pittsburgh Epidemiology of Diabetes Complications (EDC) study cohort and quantify improvements by comparing two subcohorts based on year of diabetes diagnosis (1950–1964 [n = 390] vs. 1965–1980 [n = 543]). The EDC study is a prospective cohort study of 933 participants with childhood-onset (aged <17 years) type 1 diabetes diagnosed at Children’s Hospital of Pittsburgh from 1950 to 1980. Mortality ascertainment was censored 31 December 2009. Abridged cohort life tables were constructed to calculate life expectancy. Death occurred in 237 (60.8%) of the 1950–1964 subcohort compared with 88 (16.2%) of the 1965–1980 subcohort. The life expectancy at birth for those diagnosed 1965–1980 was ∼15 years greater than participants diagnosed 1950–1964 (68.8 [95% CI 64.7–72.8] vs. 53.4 [50.8–56.0] years, respectively) (P < 0.0001); this difference persisted regardless of sex or pubertal status at diagnosis. This improvement in life expectancy emphasizes the need for insurance companies to update analysis of the life expectancy of those with childhood-onset type 1 diabetes because weighting of insurance premiums is based on outdated estimates.
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影响因子：
120.7
作者：
Narayan, KMV;Boyle, JP;Williamson, DF
通讯作者：
Williamson, DF
影响因子：
16.2
作者：
Brown, LJ;Scott, RS;Moir, CL
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120.7
作者：
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Grönhagen-Riska, C
影响因子：
13.2
作者：
Nishimura, R;Dorman, JS;Orchard, TJ
通讯作者：
Orchard, TJ
影响因子：
7.7
作者：
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通讯作者：
FinnDiane Study Group