A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes.
A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes.
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DOI：
10.1016/j.cub.2008.08.061
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发表时间：
2008-09-23
期刊：
影响因子：
9.2
通讯作者：
Fuller, Margaret T.
中科院分区：
文献类型：
--
作者：
Szafer-Glusman, Edith;Giansanti, Maria Grazia;Nishihama, Ryuichi;Bolival, Benjamin;Pringle, John;Gatti, Maurizio;Fuller, Margaret T.
细胞形状和膜重塑依赖于细胞皮层的脂质双层和细胞骨架阵列之间的调节相互作用。在胞质分裂过程中，动物细胞在赤道皮质处建立一个固定在质膜上的肌动球蛋白环。环收缩结合质膜侵入分离两个子细胞。质膜脂质影响膜的生物物理性质，如膜的曲率和弹性，并在细胞功能中发挥积极作用，专门的膜结构域正在成为调节细胞骨架组装和重排的重要因素。在这里，我们表明，突变的基因键，它编码的果蝇家族成员的Elovl蛋白介导的延长非常长链的脂肪酸，块或显着减缓分裂精母细胞分裂末期早期的分裂沟侵入。在分裂后期的键突变细胞中，收缩环经常从皮层脱离并收缩或塌陷到细胞的一侧，并且分裂沟退化。我们的研究结果牵连非常长链脂肪酸或其衍生物的复杂脂质在允许柔软的膜变形和稳定的连接皮层收缩组件的质膜在细胞分裂过程中。
Cell shape and membrane remodeling rely on regulated interactions between the lipid bilayer and cytoskeletal arrays at the cell cortex. During cytokinesis, animal cells build an actomyosin ring anchored to the plasma membrane at the equatorial cortex. Ring constriction coupled to plasma membrane ingression separates the two daughter cells. Plasma-membrane lipids influence membrane biophysical properties such as membrane curvature and elasticity and play an active role in cell function, and specialized membrane domains are emerging as important factors in regulating assembly and rearrangement of the cytoskeleton. Here we show that mutations in the gene bond, which encodes a Drosophila member of the family of Elovl proteins that mediate elongation of very-long-chain fatty acids, block or dramatically slow cleavage-furrow ingression during early telophase in dividing spermatocytes. In bond-mutant cells at late stages of division, the contractile ring frequently detaches from the cortex and constricts or collapses to one side of the cell, and the cleavage furrow regresses. Our findings implicate very-long-chain fatty acids or their derivative complex lipids in allowing supple membrane deformation and the stable connection of cortical contractile components to the plasma membrane during cell division.
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DOI：
10.1073/pnas.0608142104
发表时间：
2007-03-13
影响因子：
11.1
作者：
Chertemps, Thomas;Duportets, Line;Wicker-Thomas, Claude
通讯作者：
Wicker-Thomas, Claude
影响因子：
3.3
作者：
Giansanti, MG;Farkas, RM;Gatti, M
通讯作者：
Gatti, M
ELO2 和 ELO3 是酿酒酵母 ELO1 基因的同源物，它们在脂肪酸伸长过程中发挥作用，并且是鞘脂形成所必需的
影响因子：
4.8
作者：
Oh, CS;Toke, DA;Martin, CE
通讯作者：
Martin, CE
影响因子：
4.1
作者：
Schneiter, R;Brügger, B;Epand, RM
通讯作者：
Epand, RM
DOI：
10.1083/jcb.149.3.707
发表时间：
2000-05-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Tvrdik P;Westerberg R;Silve S;Asadi A;Jakobsson A;Cannon B;Loison G;Jacobsson A
通讯作者：
Jacobsson A