Peptidoglycan recognition proteins in hematophagous arthropods.

Peptidoglycan recognition proteins in hematophagous arthropods.
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食血节肢动物中的肽聚糖识别蛋白

DOI:
10.1016/j.dci.2017.12.017
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发表时间:
2018-06
影响因子:
2.9
通讯作者:
Wang M
Wang M
中科院分区:
生物学3区
文献类型:
--
作者:
Wang J;Song X;Wang M

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吸血节肢动物是医学上重要的疾病媒介,传播多种病原体。与利用先天免疫和适应性免疫来清除入侵病原体的哺乳动物不同,这些载体主要依靠先天免疫系统来对抗病原体。肽聚糖识别蛋白(PGRP)是先天免疫信号通路的重要组成部分,负责识别微生物相关分子模式(MAMP),从而调节宿主与有害和有益微生物的免疫相互作用。在这里,我们回顾了一些最近的研究,在不同的载体,解决功能的PGRP在免疫调节。此外,我们还讨论了PGRPs在载体和果蝇之间的差异。
Hematophagous arthropods are medically important disease vectors that transmit a variety of pathogens. Unlike mammals that employ both innate and adaptive immunity to clear invading pathogens, these vectors rely mainly on an innate immune system to combat pathogens. Peptidoglycan recognition proteins (PGRPs) are important components of innate immune signaling pathways and are responsible for recognizing microbe-associated molecular patterns (MAMPs), thus regulating host immune interactions with both harmful and helpful microbes. Here we review a number of recent studies in different vectors that address the function of PGRPs in immune regulation. Further, we discuss the variation of PGRPs between vectors and Drosophila.
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