The Anopheles innate immune system in the defense against malaria infection.
The Anopheles innate immune system in the defense against malaria infection.
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DOI：
10.1159/000353602
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发表时间：
2014
影响因子：
5.3
通讯作者：
Dimopoulos G
中科院分区：
文献类型：
--
作者：
Clayton AM;Dong Y;Dimopoulos G
昆虫的多方面先天免疫系统能够抵抗各种病原体的感染，包括那些引起人类疟疾的病原体。按蚊传播疟疾取决于疟原虫寄生虫在昆虫载体中成功完成其生命周期，这一过程涉及与几种组织和细胞类型以及蚊子的先天免疫系统的相互作用。这篇综述将讨论我们目前对按蚊对疟原虫的先天性免疫反应以及昆虫肠道微生物群对寄生虫感染的影响。
The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite’s successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito’s innate immune system. This review will discuss our current understanding of the Anopheles mosquito’s innate immune responses against the malaria parasite Plasmodium and the influence of the insect’s intestinal microbiota on parasite infection.
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影响因子：
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Ranford-Cartwright, LC
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Dimopoulos G
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