The effect of heart rate on the heart rate variability response to autonomic interventions.
The effect of heart rate on the heart rate variability response to autonomic interventions.
复制标题
DOI：
10.3389/fphys.2013.00222
复制
发表时间：
2013
影响因子：
4
通讯作者：
Billman GE
中科院分区：
文献类型：
--
作者：
Billman GE
心率变异性（heartratevariability，HRV）是指心率（heartrate，HR）或心动周期（heartperiod，R-R interval）的逐搏变化，已成为临床和研究中量化心脏自主调节的常用工具。然而，由于HR和R-R间期之间的逆曲线关系，HR本身可以深刻地影响HRV，这一点没有得到广泛的认识。因此，针对主要HR校正HRV是至关重要的，特别是当HR响应于自主神经激活或抑制而变化时。本研究在犬模型中评价了HR对自主神经活动增加（次极量运动，n = 25或压力感受器反射激活，n = 20）或减少（药物阻断：β-肾上腺素能受体、毒蕈碱受体拮抗剂单独和联合给药，n = 25，或双侧颈部迷走神经切断术，n = 9）的自主神经干预的HRV反应的影响。在自主神经干预之前和对自主神经干预的响应中确定总的（RR间期标准差，RRSD）和高频（HF）变异性（HF，0.24-1.04 Hz）。所有减少或消除心脏副交感神经调节的干预措施即使在HR校正后也会引起HRV大幅降低[分别除以RRSD和HF的平均RRsec或（平均RRsec）2]，而减少HR的干预措施产生混合结果。β-肾上腺素能受体阻滞剂降低了HRV（RRSD，但不是HF），而即使在HR校正后，RRSD和HF也会因动脉血增加而增加（压力感受器反射激活）。这些数据表明，心率变异性的生理基础，揭示了校正后的普遍的HR，进一步，心脏副交感神经活动是负责的一个主要部分的HRV在狗。
Heart rate variability (HRV), the beat-to-beat variation in either heart rate (HR) or heart period (R-R interval), has become a popular clinical and investigational tool to quantify cardiac autonomic regulation. However, it is not widely appreciated that, due to the inverse curvilinear relationship between HR and R-R interval, HR per se can profoundly influence HRV. It is, therefore, critical to correct HRV for the prevailing HR particularly, as HR changes in response to autonomic neural activation or inhibition. The present study evaluated the effects of HR on the HRV response to autonomic interventions that either increased (submaximal exercise, n = 25 or baroreceptor reflex activation, n = 20) or reduced (pharmacological blockade: β-adrenergic receptor, muscarinic receptor antagonists alone and in combination, n = 25, or bilateral cervical vagotomy, n = 9) autonomic neural activity in a canine model. Both total (RR interval standard deviation, RRSD) and the high frequency (HF) variability (HF, 0.24–1.04 Hz) were determined before and in response to an autonomic intervention. All interventions that reduced or abolished cardiac parasympathetic regulation provoked large reductions in HRV even after HR correction [division by mean RRsec or (mean RRsec)2 for RRSD and HF, respectively] while interventions that reduced HR yielded mixed results. β-adrenergic receptor blockade reduced HRV (RRSD but not HF) while both RRSD and HF increased in response to increases in arterial blood (baroreceptor reflex activation) even after HR correction. These data suggest that the physiological basis for HRV is revealed after correction for prevailing HR and, further, that cardiac parasympathetic activity is responsible for a major portion of the HRV in the dog.
登录
查看更多内容
影响因子：
1.3
作者：
Sacha, J;Pluta, W
通讯作者：
Pluta, W
影响因子：
4
作者：
Billman GE
通讯作者：
Billman GE
DOI：
10.1016/0735-1097(89)90408-7
发表时间：
1989-11-01
影响因子：
24
作者：
APPEL, ML;BERGER, RD;COHEN, RJ
通讯作者：
COHEN, RJ
影响因子：
--
作者：
COLLINS, MN;BILLMAN, GE
通讯作者：
BILLMAN, GE
DOI：
10.1152/ajpheart.1999.276.1.h215
发表时间：
1999-01-01
影响因子：
4.8
作者：
Houle, MS;Billman, GE
通讯作者：
Billman, GE