Comparative genomics of cell envelope components in mycobacteria.
Comparative genomics of cell envelope components in mycobacteria.
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DOI：
10.1371/journal.pone.0019280
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发表时间：
2011-05-06
期刊：
影响因子：
3.7
通讯作者：
Joshi R
中科院分区：
文献类型：
--
作者：
Banerjee R;Vats P;Dahale S;Kasibhatla SM;Joshi R
分枝杆菌细胞被膜组分一直是研究的主要焦点，这是由于其独特的特征，除了作为低渗透性屏障之外，还赋予对抗生素和化学品的内在抗性。已知分枝杆菌分泌的复合脂质引起/抑制宿主免疫应答，从而有助于其致病性。这项研究的重点是比较基因组学的生物合成机制的细胞壁组件在21个分枝杆菌基因组在GenBank发布179.0。对不同环境中生存的洞察可以归因于其生物合成机制的变化。本研究中检测到ufaA 1基因的基因特异性基序如“DLLAQPTPAW”，新的功能键如Rv 0227 c参与霉菌酸生物合成，Rv 2613 c参与LAM生物合成，Rv 1209参与阿拉伯半乳聚糖肽聚糖生物合成。这些预测与来自TBDB的可用的突变体和共表达数据很好地相关。它还有助于获得这些生物合成途径的最小功能基因集，以补充使用TraSH的发现。
Mycobacterial cell envelope components have been a major focus of research due to their unique features that confer intrinsic resistance to antibiotics and chemicals apart from serving as a low-permeability barrier. The complex lipids secreted by Mycobacteria are known to evoke/repress host-immune response and thus contribute to its pathogenicity. This study focuses on the comparative genomics of the biosynthetic machinery of cell wall components across 21-mycobacterial genomes available in GenBank release 179.0. An insight into survival in varied environments could be attributed to its variation in the biosynthetic machinery. Gene-specific motifs like ‘DLLAQPTPAW’ of ufaA1 gene, novel functional linkages such as involvement of Rv0227c in mycolate biosynthesis; Rv2613c in LAM biosynthesis and Rv1209 in arabinogalactan peptidoglycan biosynthesis were detected in this study. These predictions correlate well with the available mutant and coexpression data from TBDB. It also helped to arrive at a minimal functional gene set for these biosynthetic pathways that complements findings using TraSH.
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