Harmonizing finite element modelling for non-invasive strength estimation by high-resolution peripheral quantitative computed tomography.
Harmonizing finite element modelling for non-invasive strength estimation by high-resolution peripheral quantitative computed tomography.
复制标题
通过高分辨率外围定量计算机断层扫描协调有限元建模以进行非侵入性强度估计。
DOI：
10.1016/j.jbiomech.2018.08.030
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发表时间：
2018
影响因子：
2.4
通讯作者：
Boyd,StevenK
中科院分区：
文献类型：
--
作者：
Whittier,DanielleE;Manske,SarahL;Kiel,DouglasP;Bouxsein,Mary;Boyd,StevenK
基于高分辨率外周定量CT(HR-pQCT)的有限元方法在不同的实验室使用了多种组织本构特性和边界条件，使得力学特性的比较变得困难。此外，由于分辨率的提高和更大的感兴趣区域(ROI)，第二代HR-pQCT的出现带来了挑战。这项研究解决了协调所有有限元模型结果的需要。其目的是建立作为第一代HR-pQCT系统的边界条件的函数的FE结果与一系列组织属性之间的关系，并为第二代HR-pQCT系统确定合适的模型参数。我们在一个大的队列(N = 1371)上实现了共同的边界条件和组织属性，并且显示了FE模型之间的屈服强度和反作用力之间的高度线性关系(R2>； 0.99)。在两代HR-PQCT上测量的身体半径与匹配的ROI被用来反向计算导致分辨率增加的组织弹性系数(61 微米对82 微米)，结果是第二代HR-PQCT的弹性系数为8748 Mpa，产生的骨屈服强度和反作用力相当于第一代HR-PQCT的6829 Mpa。最后，在两代人身上进行的活体扫描(N = 61)显示，第二代系统中更大的ROI导致更强的骨结果指标，这表明在没有匹配ROI的情况下，不建议跨HR-pQCT代间转换FE结果。总而言之，这些发现通过提供一种方法来比较不同边界条件和组织特性以及跨扫描仪的结果，从而协调FE结果。
The finite element (FE) method based on high-resolution peripheral quantitative computed tomography (HR-pQCT) use a variety of tissue constitutive properties and boundary conditions at different laboratories making comparison of mechanical properties difficult. Furthermore, the advent of a second-generation HR-pQCT poses challenges due to improved resolution and a larger region of interest (ROI). This study addresses the need to harmonize results across FE models. The aims are to establish the relationship between FE results as a function of boundary conditions and a range of tissue properties for the first-generation HR-pQCT system, and to determine appropriate model parameters for the second-generation HR-pQCT system. We implemented common boundary conditions and tissue properties on a large cohort (N = 1371), and showed the relationships were highly linear (R2> 0.99) for yield strength and reaction force between FE models. Cadaver radii measured on both generation HR-pQCT with matched ROIs were used to back-calculate a tissue modulus that accounts for the increased resolution (61 µm versus 82 µm), resulting in a modulus of 8748 MPa for second-generation HR-pQCT to produce bone yield strength and reaction force equivalent to using 6829 MPa for first-generation HR-pQCT. Finally,in vivoscans (N = 61) conducted on both generations demonstrated that the larger ROI in the second-generation system results in stronger bone outcome measures, suggesting it is not advisable to convert FE results across HR-pQCT generations without matching ROIs. Together, these findings harmonize FE results by providing a means to compare findings with different boundary conditions and tissue properties, and across scanner generations.
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影响因子：
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作者：
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影响因子：
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影响因子：
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