Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: The STRAMBO study
Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: The STRAMBO study
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肌肉质量和握力较低的老年男性桡骨远端骨微结构受损：STRAMBO 研究
DOI：
10.1002/jbmr.1726
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发表时间：
2013
影响因子：
6.2
通讯作者：
R. Chapurlat
中科院分区：
文献类型：
--
作者：
P. Szulc;S. Blaizot;S. Boutroy;N. Vilayphiou;S. Boonen;R. Chapurlat
其目的是研究老年男性骨骼微结构与肌肉质量和力量之间的关系。通过高分辨率外周计算机断层扫描（HR-pQCT）评估了810名年龄≥60岁男性桡骨远端的体积骨矿物质密度（vBMD）和骨微结构。通过双能X射线吸收测定法（DXA）评估面积骨矿物质密度（aBMD）和阑尾肌肉质量（ASM）。上肢相对ASM（RASM-u.l.）计算为上肢ASM/（身高）2。通过测力计测量握力。在多变量模型中，最低RASM-u. l.与最高四分位数的男性相比，四分位数的男性桡骨远端横截面积（CSA）、皮质面积（Ct.Ar）、皮质厚度（Ct.Th）和骨小梁面积（Tb.Ar）较低。在调整握力后，趋势仍然显着。标准化握力最低四分位数（握力/[身高]2）的男性aBMD、总vBMD、Ct.Ar、Ct.Th、Tb.vBMD和Tb.N较低，Tb.Sp和Tb. Sp. SD较高。校正RASM-u. l后，Ct.Ar、总vBMD、Ct.Th、Tb.vBMD和Tb.Sp的相关性仍然显著。在包括RASM‐u.l.标准化握力、CSA和Tb.Ar与RASM-u. l相关。但没有力气较低的Ct.Th、Tb.vBMD和Tb.N与较低的握力相关，但与RASM-u. l无关。较低的Ct.Ar与较低的握力和较低的RASM-u. l相关。总之，在老年男性中，低RASM-u.l.在调整混杂因素后，低握力与皮质和小梁微结构不良相关，部分相互独立。© 2013美国骨与矿物质研究学会
The aim was to study the association between bone microarchitecture and muscle mass and strength in older men. Volumetric bone mineral density (vBMD) and bone microarchitecture were assessed in 810 men aged ≥60 years at the distal radius by high‐resolution peripheral computed tomography (HR‐pQCT). Areal bone mineral density (aBMD) and appendicular muscle mass (ASM) were assessed by dual‐energy X‐ray absorptiometry (DXA). Relative ASM of the upper limbs (RASM‐u.l.) was calculated as ASM of the upper limbs/(height)2. Grip strength was measured by dynanometry. In multivariable models, men in the lowest RASM‐u.l. quartile had lower cross‐sectional area (CSA), cortical area (Ct.Ar), cortical thickness (Ct.Th), and trabecular area (Tb.Ar) at distal radius compared with men in the highest quartile. The trends remained significant after adjustment for grip strength. Men in the lowest quartile of the normalized grip strength (grip strength/[height]2) had lower aBMD, total vBMD, Ct.Ar, Ct.Th, Tb.vBMD, and Tb.N, and higher Tb.Sp and Tb.Sp.SD. The associations for Ct.Ar, total vBMD, Ct.Th, Tb.vBMD, and Tb.Sp remained significant after adjustment for RASM‐u.l. In the models including RASM‐u.l. and normalized grip strength, CSA and Tb.Ar were associated with RASM‐u.l. but not with the strength. Lower Ct.Th, Tb.vBMD, and Tb.N were associated with lower grip strength but not with RASM‐u.l. Lower Ct.Ar was associated with lower grip strength and with lower RASM‐u.l. In conclusion, in older men, low RASM‐u.l. and low grip strength are associated with poor cortical and trabecular microarchitecture partly independently of each other, after adjustment for confounders. © 2013 American Society for Bone and Mineral Research
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影响因子：
7.1
作者：
Baumgartner, RN;Stauber, PM;Garry, PJ
通讯作者：
Garry, PJ
DOI：
10.1093/gerona/glr010
发表时间：
2012-01-01
影响因子：
5.1
作者：
Manini, Todd M.;Clark, Brian C.
通讯作者：
Clark, Brian C.
影响因子：
5
作者：
Baumgartner, RN;Koehler, KM;Lindeman, RD
通讯作者：
Lindeman, RD
DOI：
10.1093/gerona/61.10.1059
发表时间：
2006-10-01
影响因子：
5.1
作者：
Goodpaster, Bret H.;Park, Seok Won;Newman, Anne B.
通讯作者：
Newman, Anne B.