The role of smoking history in longitudinal changes in C-reactive protein between Black and White older adults in the US.
The role of smoking history in longitudinal changes in C-reactive protein between Black and White older adults in the US.
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DOI：
10.1016/j.pmedr.2022.101885
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发表时间：
2022-08
影响因子：
2.8
通讯作者：
Tan, Marcia M.
中科院分区：
文献类型：
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作者：
Jao, Nancy C.;Martinez-Cardoso, Aresha;Vahora, Moin;Tan, Marcia M.
这项研究是第一个研究种族和吸烟史对CRP变化的影响。总体而言，种族或目前吸烟对CRP变化没有显著影响。仅在NHW中，吸烟史、教育、性别和BMI是CRP的预测因素。仅在NHB中，只有BMI预测CRP。NHB可能不会经历与NHWs相同的戒烟后CRP的降低。戒烟与C反应蛋白（CRP）的降低有关，CRP是全身炎症和癌症风险的生物标志物;然而，与从不吸烟的人相比，戒烟的人的CRP水平长期保持较高。虽然非西班牙裔、黑人/非裔美国人（NHB）的CRP水平高于非西班牙裔、白色/高加索人（NHW）成人，但尚未在有吸烟史的个体中检查CRP与种族之间的相关性。利用健康与退休研究（HRS）的纵向数据，目前的研究检查了种族和吸烟史对老年人CRP的影响。NHB（n = 242）和NHW（n = 1529）参与者在2006年、2010年和2014年完成了HRS评估。在每个波收集的干血点进行CRP测定。使用线性混合模型来检查种族和吸烟史对CRP的影响-控制社会人口统计学，体力活动，体重指数（BMI）和当前吸烟。总体而言，结果显示种族或当前吸烟对CRP没有显著影响;而年龄、性别、教育、BMI、体力活动、吸烟史和时间×种族可预测CRP（ps<.04）。然而，在种族分层模型中，年龄、性别、教育程度、BMI、体力活动和吸烟史也是NHWs中CRP的预测因子（p <0.04），而只有BMI是NHB中CRP的显著预测因子（p= 0.012）。BMI在解释有吸烟史的NHB患者炎症相关疾病风险方面可能很重要。NHB可能不会经历与NHW相同的戒烟后CRP降低-可能导致烟草相关的健康差异。
This study is the first to examine the effect of race and smoking history on changes in CRP. Overall, there were no significant effects of race or current cigarette smoking on CRP change. In NHWs only, smoking history, education, sex, and BMI were predictive of CRP. In NHBs only, only BMI was predictive of CRP. NHBs may not experience the same reductions in CRP with smoking cessation as NHWs. Smoking cessation is associated with decreases in C-reactive protein (CRP), a biomarker of systemic inflammation and cancer risk; yet CRP levels remain higher long-term in individuals who quit vs. those who never smoked. While non-Hispanic, Black/African American (NHB) have higher levels of CRP vs. non-Hispanic, White/Caucasian (NHW) adults, the association between CRP and race has not been examined in individuals with smoking history. Utilizing longitudinal data from the Health and Retirement Study (HRS), the current study examined the effects of race and smoking history on CRP in older adults. NHB (n = 242) and NHW (n = 1529) participants completed HRS assessments in 2006, 2010, and 2014. Dried blood spots collected at each wave were assayed for CRP. Linear mixed models were used to examine the effect of race and smoking history on CRP across waves – controlling for sociodemographics, physical activity, body mass index (BMI), and current smoking. Overall, results showed no significant effects of race or current smoking on CRP; rather age, sex, education, BMI, physical activity, smoking history, and time × race predicted CRP (ps<.04). However, while age, sex, education, BMI, physical activity, and smoking history were also predictive of CRP in NHWs (ps<.04) in race-stratified models, only BMI was a significant predictor of CRP in NHBs (p=.012). BMI may be important in explaining inflammation-related disease risk in NHBs with a history of smoking. NHBs may not experience the same reductions in CRP with smoking cessation as NHWs – potentially contributing to tobacco-related health disparities.
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DOI：
10.1158/1055-9965.epi-14-0064
发表时间：
2014-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Brenner DR;Scherer D;Muir K;Schildkraut J;Boffetta P;Spitz MR;Le Marchand L;Chan AT;Goode EL;Ulrich CM;Hung RJ
通讯作者：
Hung RJ
影响因子：
20.4
作者：
Meaney, Claire L.;Mitchell, Khadijah A.;Ryan, Brid M.
通讯作者：
Ryan, Brid M.
成人目前吸烟 - 美国，2016年。
DOI：
10.15585/mmwr.mm6702a1
发表时间：
2018-01-19
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Jamal A;Phillips E;Gentzke AS;Homa DM;Babb SD;King BA;Neff LJ
通讯作者：
Neff LJ
影响因子：
0.9
作者：
Bronars, Carrie A.;Faseru, Babalola;Cox, Lisa Sanderson
通讯作者：
Cox, Lisa Sanderson
影响因子：
45.3
作者：
Chaturvedi, Anil K.;Caporaso, Neil E.;Engels, Eric A.
通讯作者：
Engels, Eric A.