Clinical approaches to treating papillary squamous cell carcinoma of the uterine cervix.
Clinical approaches to treating papillary squamous cell carcinoma of the uterine cervix.
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DOI：
10.1186/1471-2407-14-784
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发表时间：
2014-10-27
期刊：
影响因子：
3.8
通讯作者：
Konishi I
中科院分区：
文献类型：
--
作者：
Nagura M;Koshiyama M;Matsumura N;Kido A;Baba T;Abiko K;Hamanishi J;Yamaguchi K;Mikami Y;Konishi I
宫颈乳头状鳞状细胞癌(PSCC)很难诊断，因为它很罕见，而且关于其临床行为的数据有限。我们试图用磁共振成像(MRI)评估间质侵犯的程度，并根据其临床行为评估可能的治疗方法。对镜下选择性活检诊断的28例PSCC进行了分析。研究镜下选择性活检的诊断准确率与最终诊断的符合率，并将MRI与病理结果的间质侵袭率进行比较，重点探讨手术方法和临床预后。在28例患者中，只有12例显示为真正的PSCC。根据手术标本的发现，其他16名患者最终被诊断为鳞癌或腺鳞状细胞癌，并显示出相对较差的预后。在12例真性PSCC中，镜下选择性活检对间质侵犯的诊断准确率仅为58%(7/12)。然而，我们能够在手术前使用MRI预测间质侵犯的存在(显微边界：大约3毫米)。接受根治性手术的10例患者中，无一例出现淋巴结转移。此外，所有12名研究患者都没有复发(平均49个月)，并存活了下来。MRI可用于术前检测侵袭前疾病和微侵袭疾病。鉴于PSCC的惰性临床表现，在侵袭前和微侵袭的PSCC病例中，有可能选择一种比根治性手术侵袭性更小的手术方法。本文的在线版本(DOI：10.1186/1471-2407-14-784)包含补充材料，可供授权用户使用。
Papillary squamous cell carcinoma (PSCC) of the uterine cervix is difficult to diagnose due to its rarity and limited data regarding its clinical behavior. We attempted to assess the degree of stromal invasion using magnetic resonance imaging (MRI) and evaluate possible treatments for this lesion in view of its clinical behavior. We analyzed 28 cases of PSCC diagnosed on the colposcopic selective biopsies. We studied the rate of accuracy of diagnoses of the colposcopic selective biopsies compared with the final diagnoses, and compared the rate of stromal invasion between the MRI and pathological findings while focusing on surgical methods and the clinical prognosis. Of the 28 patients, only 12 exhibited true PSCC. The other 16 patients were ultimately diagnosed with SCC or adenosquamous carcinoma based on the finding of the surgical specimens and exhibited relatively poor prognoses. Among the 12 true PSCC cases, the rate of diagnostic accuracy of stromal invasion (with or without) was only 58% (7/12) on the colposcopic selective biopsies. However, we were able to predict the presence of stromal invasion (microscopic borderline: approximately 3 mm) before surgery using MRI. None of the 10 patients treated with radical surgery displayed lymph node metastases. In addition, all 12 study patients exhibited no recurrence (mean: 49 months) and survived. MRI can be used to detect preinvasive and microinvasive disease before surgery. It is possible to select a less invasive surgical method than radical surgery in cases of preinvasive and microinvasive PSCC in view of the indolent clinical behavior of this disease. The online version of this article (doi:10.1186/1471-2407-14-784) contains supplementary material, which is available to authorized users.
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DOI：
10.1034/j.1600-0412.2002.810217.x
发表时间：
2002-02-01
影响因子：
4.3
作者：
Fujimoto, T;Sakuragi, N;Fujimoto, S
通讯作者：
Fujimoto, S
DOI：
10.1097/00004347-198603000-00001
发表时间：
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影响因子：
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影响因子：
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DOI：
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发表时间：
2011-01-01
期刊：
BLAUSTEIN'S PATHOLOGY OF THE FEMALE GENITAL TRACT, SIXTH EDITION
影响因子：
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作者：
Witkiewicz, Agnieszka K.;Wright, Thomas C.;Kurman, Robert J.
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影响因子：
5.6
作者：
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