Coordinated regulation of the metabolome and lipidome at the host-microbial interface.
Coordinated regulation of the metabolome and lipidome at the host-microbial interface.
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DOI：
10.1016/j.bbalip.2009.09.009
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Crawford PA
中科院分区：
文献类型：
--
作者：
Bäckhed F;Crawford PA
创造性地使用gnotobiotic动物，再加上现代宏基因组测序平台和生物标本的代谢组学分析的发展，赋予了新的见解宿主哺乳动物和其居民微生物群之间非常复杂的界面。作为相互的恩人，每个合作伙伴都表现出适应的证据：宿主提供了一个好客的栖息地，考虑到自己的物种起源，饮食，基因型，地理位置，疾病的存在或不存在，以及药物的使用;微生物群，反过来，配置其选区，集体基因组（微生物组），转录组和代谢组，以最佳地适应其生态位。在这篇综述中，我们讨论了肠道微生物群及其宿主合作调节脂质代谢的机制，从而影响对营养摄入的代谢反应，并最终影响肥胖和脂毒性等相关疾病的发展。因此，这些研究表明，肠道微生物群是一种“环境”影响，其与宿主的协同相互依存关系强烈表明，我们实际上是“超生物体”。
The creative use of gnotobiotic animals, coupled with the development of modern metagenomic sequencing platforms and metabolomic profiling of biospecimens, has bestowed new insight into the remarkably intricate interface between the host mammal and its resident microbiota. As mutual benefactors, each partner exhibits evidence of adaptation: the host provides a hospitable habitat, giving consideration to its own species of origin, diet, genotype, geographical location, presence or absence of disease, and use of medications; the microbiota, in turn, configures its constituency, collective genome (microbiome), transcriptome, and metabolome to optimally suit its ecological niche. In this review, we discuss the mechanisms through which the gut microbiota and its host collaborate to regulate lipid metabolism, thereby influencing the metabolic response to nutrient intake and ultimately, the development of obesity and associated diseases such as lipotoxicity. These studies therefore demonstrate that the gut microbiota is an `environmental' influence whose synergistic interdependence with its host strongly suggests that we are in fact `supraorganisms'.
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