Locus coeruleus anchors a trisynaptic circuit controlling fear-induced suppression of feeding.
Locus coeruleus anchors a trisynaptic circuit controlling fear-induced suppression of feeding.
复制标题
蓝斑锚定控制恐惧引起的摄食抑制的三突触回路。
DOI：
10.1016/j.neuron.2020.12.023
复制
发表时间：
2021-03-03
期刊：
影响因子：
16.2
通讯作者：
Surmeier, D. James
中科院分区：
文献类型：
--
作者：
Yang, Ben;Sanches-Padilla, Javier;Kondapalli, Jyothisri;Morison, Sage L.;Delpire, Eric;Awatramani, Rajeshwar;Surmeier, D. James
恐惧诱导的进食抑制背后的回路机制还知之甚少。为了帮助填补这一缺口，小鼠接受了恐惧条件反射，并研究了由此导致的蓝斑(LC)、臂旁核(PBN)和杏仁中央核(CEA)之间突触连接的变化-所有这些都与恐惧和进食有关。LC神经元共同释放去甲肾上腺素和谷氨酸，兴奋PBN神经元，抑制摄食。LC神经元还通过诱导CEA突触的异突性、内源性大麻素依赖、长期抑制来抑制向PBN神经元的抑制性输入。阻断或击倒CEA神经元中的内源性大麻素受体可阻止恐惧导致的CEA突触传递抑制和恐惧导致的摄食抑制。总之，这些研究表明，LC神经元在调节恐惧诱导的进食抑制背后的电路中发挥着关键作用，为缓解应激诱导的饮食障碍指明了新的方法。Yang等人。证明蓝斑神经元通过直接激活臂旁核神经元并诱导其来自杏仁核的抑制输入的长期抑制来协调恐惧诱导的摄食抑制。蓝斑神经元的这种双重调节是通过去甲肾上腺素和谷氨酸的共同释放来调节的。
The circuit mechanisms underlying fear-induced suppression of feeding are poorly understood. To help fill this gap, mice were fear conditioned, and the resulting changes in synaptic connectivity among the locus coeruleus (LC), the parabrachial nucleus (PBN), and the central nucleus of amygdala (CeA)—all of which are implicated in fear and feeding—were studied. LC neurons co-released noradrenaline and glutamate to excite PBN neurons and suppress feeding. LC neurons also suppressed inhibitory input to PBN neurons by inducing heterosynaptic, endocannabinoid-dependent, long-term depression of CeA synapses. Blocking or knocking down endocannabinoid receptors in CeA neurons prevented fear-induced depression of CeA synaptic transmission and fear-induced suppression of feeding. Altogether, these studies demonstrate that LC neurons play a pivotal role in modulating the circuitry that underlies fear-induced suppression of feeding, pointing to new ways of alleviating stress-induced eating disorders. Yang et al. demonstrate that locus coeruleus neurons orchestrate fear-induced suppression of feeding by directly activating the parabrachial nucleus neurons and inducing long-term depression of their inhibitory inputs from the amygdala. This dual regulation by locus coeruleus neurons is mediated by co-release of noradrenaline and glutamate.
登录
查看更多内容
影响因子：
2.7
作者：
da Silva, Eduardo Simao;Flores, Rafael Appel;Paschoalini, Marta Aparecida
通讯作者：
Paschoalini, Marta Aparecida
影响因子：
64.8
作者：
Ciocchi, Stephane;Herry, Cyril;Luethi, Andreas
通讯作者：
Luethi, Andreas
影响因子：
29
作者：
Campos CA;Bowen AJ;Schwartz MW;Palmiter RD
通讯作者：
Palmiter RD
影响因子：
17.7
作者：
Geracioti, TD;Baker, DG;Kasckow, JW
通讯作者：
Kasckow, JW
影响因子：
3.4
作者：
GRENHOFF, J;NORTH, RA;JOHNSON, SW
通讯作者：
JOHNSON, SW