Exploration of small RNAs.
Exploration of small RNAs.
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DOI：
10.1371/journal.pgen.0040022
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发表时间：
2008-01
期刊：
影响因子：
4.5
通讯作者：
Hayashizaki Y
中科院分区：
文献类型：
--
作者：
Kawaji H;Hayashizaki Y
几十年来，只有有限数量的非编码RNA，如核糖体和转移RNA，已被深入研究。近年来，越来越多的非编码RNA被发现。其中，小RNA种类吸引了特别的兴趣，因为它们在RNA沉默和修饰等过程中的重要作用。详细的分析揭示了与小RNA功能相关的几种途径。虽然这些途径显示进化保守性，但存在实质性差异。先进的RNA分析技术加速了这一领域的发展，导致越来越多的新物种被发现，这表明我们才刚刚开始认识到小RNA及其功能的复杂性。本文综述了近年来小RNA分子的研究进展，包括发现的小RNA分子种类、它们的分子通路和设计的技术。
For several decades, only a limited number of noncoding RNAs, such as ribosomal and transfer RNA, have been studied in any depth. In recent years, additional species of noncoding RNAs have increasingly been discovered. Of these, small RNA species attract particular interest because of their essential roles in processes such as RNA silencing and modifications. Detailed analyses revealed several pathways associated with the function of small RNAs. Although these pathways show evolutional conservation, there are substantial differences. Advanced technologies to profile RNAs have accelerated the field further resulting in the discovery of an increasing number of novel species, suggesting that we are only just beginning to appreciate the complexity of small RNAs and their functions. Here, we review recent progress in novel small RNA exploration, including discovered small RNA species, their pathways, and devised technologies.
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