Towards a Biocompatible, Biodegradable Copolymer Incorporating Electroactive Oligothiophene Units.
Towards a Biocompatible, Biodegradable Copolymer Incorporating Electroactive Oligothiophene Units.
复制标题
DOI：
10.1021/ma8019859
复制
发表时间：
2009
期刊：
影响因子：
5.5
通讯作者：
Schmidt, Christine E.
中科院分区：
文献类型：
--
作者：
Guimard, Nathalie K. E.;Sessler, Jonathan L.;Schmidt, Christine E.
作为开发生物相容性、可生物降解导电聚合物的持续努力的一部分，我们在这里报道了一种新型共聚物的合成和表征，5,5 ‘ ’双羟基甲基-3,3 ' '-二甲基-2,2':5',2 ':5',2 ' '-季噻吩-共己二酸聚酯（QAPE）。该体系旨在将交替电活性季噻吩单元和可生物降解的酯单元整合到一个大分子框架中，同时允许通过缩聚反应轻松制备聚合物。与设计预期一致，从标准化学和光谱分析推断，发现酯基团被纳入到聚合物中，介于季噻吩亚基之间。通过循环伏安法检测，QAPE表现出氧化还原活性，并在掺杂后出现了新的红移吸收峰，这支持了季噻吩单元在加入QAPE聚合物框架后保持电活性的观点。在胆固醇酯酶存在的情况下，这种聚合物的降解可能是通过表面侵蚀，通过检测与季硫吩亚基对应波长的荧光信号并与适当的对照进行比较，证实了这种聚合物的降解。体外48小时细胞相容性研究表明，QAPE聚合物对雪旺细胞无毒。
As part of an ongoing effort to develop biocompatible, biodegradable conducting polymers, we report here the synthesis and characterization of a novel copolymer, 5,5"'bishydroxymethyl-3,3"'-dimethyl-2,2':5',2":5",2"'-quaterthiophene-co-adipic acid polyester (QAPE). This system was designed so as to incorporate alternating electroactive quaterthiophene units and biodegradable ester units into one macromolecular framework, while allowing for facile preparation of the polymer via a polycondensation reaction. In agreement with the design expectations, the ester groups were found to be incorporated into the polymer between the quaterthiophene subunits, as inferred from standard chemical and spectroscopic analyses. QAPE exhibited redox activity as detected by cyclic voltammetry and a new red-shifted absorption peak upon doping, providing support for the notion that the quaterthiophene units maintain electroactivity after incorporation into the QAPE polymer framework. The degradation, likely through surface erosion, of this polymer in the presence of cholesterol esterase was confirmed by the detection of a fluorescence signal at wavelengths corresponding to the quaterthiophene subunit and comparisons to appropriate controls. In vitro cytocompatability studies, carried out over 48 h, indicate that the QAPE polymer is nontoxic to Schwann cells.
登录
查看更多内容
影响因子：
64.8
作者：
BASSETT, CA;PAWLUK, RJ;BECKER, RO
通讯作者：
BECKER, RO
影响因子：
14
作者：
Cui, XY;Wiler, J;Martin, DC
通讯作者：
Martin, DC
DOI：
10.2106/00004623-198163040-00001
发表时间：
1981-01-01
影响因子：
5.3
作者：
BASSETT, CAL;MITCHELL, SN;GASTON, SR
通讯作者：
GASTON, SR
影响因子：
29.4
作者：
Abidian, MR;Kim, DH;Martin, DC
通讯作者：
Martin, DC
影响因子：
8.4
作者：
Cui, XY;Martin, DC
通讯作者：
Martin, DC