Nearest neighbor parameters for Watson-Crick complementary heteroduplexes formed between 2'-O-methyl RNA and RNA oligonucleotides.
Nearest neighbor parameters for Watson-Crick complementary heteroduplexes formed between 2'-O-methyl RNA and RNA oligonucleotides.
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DOI：
10.1093/nar/gkl232
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发表时间：
2006
影响因子：
14.9
通讯作者：
Kierzek, Ryszard
中科院分区：
文献类型：
--
作者：
Kierzek, Elzbieta;Mathews, David H.;Ciesielska, Anna;Turner, Douglas H.;Kierzek, Ryszard
利用光学解链方法研究了2′-O-甲基RNA与RNA寡核苷酸形成的Watson-Crick互补异源双链体的热力学参数，并以此为基础预测了该双链体的稳定性。结果是一致的物理模型所假设的个人最近邻氢键模型，其中包含的条款螺旋起始，碱基对堆积和碱基对组合物。序列依赖性类似于沃森-克里克互补RNA/RNA双链体，这表明序列依赖性也可能类似于有利于A型RNA构象的其他主链。
Results from optical melting studies of Watson–Crick complementary heteroduplexes formed between 2′-O-methyl RNA and RNA oligonucleotides are used to determine nearest neighbor thermodynamic parameters for predicting the stabilities of such duplexes. The results are consistent with the physical model assumed by the individual nearest neighbor-hydrogen bonding model, which contains terms for helix initiation, base pair stacking and base pair composition. The sequence dependence is similar to that for Watson–Crick complementary RNA/RNA duplexes, which suggests that the sequence dependence may also be similar to that for other backbones that favor A-form RNA conformations.
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