Applying behavioral economics-based approaches to examine the effects of liquid sucrose consumption on motivation.
Applying behavioral economics-based approaches to examine the effects of liquid sucrose consumption on motivation.
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DOI：
10.1016/j.appet.2023.106556
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发表时间：
2023-07-01
期刊：
影响因子：
5.4
通讯作者：
Ferrario, Carrie R.
中科院分区：
文献类型：
--
作者：
Finnell, Julie E.;Ferrario, Carrie R.
过量摄入糖导致肥胖，部分原因是改变了大脑区域的活动，这些区域驱动着寻找和消费食物的动机。含糖饮料是过量膳食糖的最常见来源，也是体重增加的原因之一。然而，很少有研究评估液态蔗糖摄入对动机的影响。这在一定程度上是因为需要新的方法来评估临床前模型的动机。为了解决这一问题，我们开发了一种会话内行为经济学程序来评估对液体蔗糖的动机。我们首先建立并验证了程序：我们测试了几种蔗糖浓度，评估了程序对饱腹感的敏感性，并优化了几个测试参数。然后，我们应用这一新程序来确定在家中间歇和连续接触液体蔗糖(1M)对蔗糖动机的影响。我们发现，与保持水的对照组相比，间歇性接触液体蔗糖会导致家庭笼子中蔗糖摄入量的增加，而不会改变需求测试期间(1M或0.25M)对液体蔗糖的动机。相反，连续的家庭笼子进入选择性地钝化对1M蔗糖的动机，而对0.25M蔗糖的动机与间歇性蔗糖组和对照组相似。因此，连续的家庭笼式液体蔗糖接入的效果对常见的蔗糖浓度是选择性的。最后，在从饮食中去除液体蔗糖后，蔗糖对动力的影响恢复。这些数据提供了一种新的方法来检验液体蔗糖的动机，并表明摄入量的增加和蔗糖的动机是分离的过程。
Overconsumption of sugar contributes to obesity in part by changing the activity of brain areas that drive the motivation to seek out and consume food. Sugar-sweetened beverages are the most common source of excess dietary sugar and contribute to weight gain. However, very few studies have assessed the effects of liquid sucrose consumption on motivation. This is due in part to the need for novel approaches to assess motivation in pre-clinical models. To address this, we developed a within-session behavioral economics procedure to assess motivation for liquid sucrose. We first established and validated the procedure: we tested several sucrose concentrations, evaluated sensitivity of the procedure to satiety, and optimized several testing parameters. We then applied this new procedure to determine how intermittent vs. continuous access to liquid sucrose (1 M) in the home cage affects sucrose motivation. We found that intermittent liquid sucrose access results in an escalation of sucrose intake in the home cage, without altering motivation for liquid sucrose during demand testing (1 M or 0.25 M) compared to water-maintained controls. In contrast, continuous home cage access selectively blunted motivation for 1 M sucrose, while motivation for 0.25 M sucrose was similar to intermittent sucrose and control groups. Thus, effects of continuous home cage liquid sucrose access were selective to the familiar sucrose concentration. Finally, effects of sucrose on motivation recovered after removal of liquid sucrose from the diet. These data provide a new approach to examine motivation for liquid sucrose and show that escalation of intake and motivation for sucrose are dissociable processes.
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