Effect of diet on preference and intake of sucrose in obese prone and resistant rats.
Effect of diet on preference and intake of sucrose in obese prone and resistant rats.
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DOI：
10.1371/journal.pone.0111232
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Covasa M
中科院分区：
文献类型：
--
作者：
Duca FA;Swartz TD;Covasa M
可口的饮食增加口腔感觉刺激和肠道信号反馈减少已被认为是肥胖发展的促成因素。然而，与肥胖相关的味觉功能改变是否是常见的特征或对环境因素（如高能量（HE）饮食）的后天缺陷尚不清楚。为了解决这一问题，我们研究了偏好和敏感性增加浓度的蔗糖解决方案在大鼠倾向（OP）和抵抗（OR）肥胖在食物和HE喂养和测量舌基因表达的甜味受体T1 R3。当chow喂养，OP大鼠表现出减少的偏好和接受稀蔗糖溶液，假喂少蔗糖相比，OR大鼠，并减少舌T1 R3基因表达。HE喂养消除了表型之间蔗糖偏好和摄入量以及舌T1 R3表达的差异。尽管相似的蔗糖摄入量，然而，OP大鼠消耗显着更多的总热量在48小时的两瓶测试相比，OR大鼠。结果表明，OP大鼠具有甜味检测的先天缺陷，如对甜食的敏感性降低和T1 R3基因表达降低所示;然而，在HE喂养期间，它们的暴食症和随后的肥胖症很可能不是由于甜食消费的改变。
Increased orosensory stimulation from palatable diets and decreased feedback from gut signals have been proposed as contributing factors to obesity development. Whether altered taste functions associated with obesity are common traits or acquired deficits to environmental factors, such as a high-energy (HE)-diet, however, is not clear. To address this, we examined preference and sensitivity of increasing concentrations of sucrose solutions in rats prone (OP) and resistant (OR) to obesity during chow and HE feeding and measured lingual gene expression of the sweet taste receptor T1R3. When chow-fed, OP rats exhibited reduced preference and acceptance of dilute sucrose solutions, sham-fed less sucrose compared to OR rats, and had reduced lingual T1R3 gene expression. HE-feeding abrogated differences in sucrose preference and intake and lingual T1R3 expression between phenotypes. Despite similar sucrose intakes however, OP rats consumed significantly more total calories during 48-h two-bottle testing compared to OR rats. The results demonstrate that OP rats have an innate deficit for sweet taste detection, as illustrated by a reduction in sensitivity to sweets and reduced T1R3 gene expression; however their hyperphagia and subsequent obesity during HE-feeding is most likely not due to altered consumption of sweets.
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发表时间：
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影响因子：
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