Effects of poor and short sleep on glucose metabolism and obesity risk.

Effects of poor and short sleep on glucose metabolism and obesity risk.
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DOI:
10.1038/nrendo.2009.23
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发表时间:
2009-05
期刊:
Nature reviews. Endocrinology
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其他
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睡眠对荷尔蒙和葡萄糖代谢的重要性早在40多年前就有文献记载了。从那时起,减少睡眠已经成为现代社会的一种地方性行为。此外,睡眠障碍,特别是阻塞性睡眠呼吸暂停(OSA)的患病率有所增加。阻塞性睡眠呼吸暂停综合征在内分泌和代谢紊乱中非常常见,但通常仍未确诊。这篇综述综述了实验室和流行病学证据,这些证据表明,睡眠不足,无论是与行为或疾病相关的,还是睡眠质量差,可能会促进肥胖和糖尿病的发展,并加剧现有的内分泌疾病。睡眠障碍的治疗有可能改善葡萄糖代谢和能量平衡。筛查习惯性睡眠模式和阻塞性睡眠呼吸暂停可能对内分泌和代谢紊乱患者至关重要。
The importance of sleep to hormones and glucose metabolism was first documented more than four decades ago. Since then, sleep curtailment has become an endemic behavior in modern society. In addition, the prevalence of sleep disorders, particularly obstructive sleep apnea (OSA), has increased. OSA is very common in endocrine and metabolic disorders, but often remains undiagnosed. This Review summarizes the laboratory and epidemiologic evidence that suggests how sleep loss, either behavioral or disease-related, and poor quality of sleep might promote the development of obesity and diabetes mellitus, and exacerbate existing endocrine conditions. Treatment of sleep disorders has the potential to improve glucose metabolism and energy balance. Screening for habitual sleep patterns and OSA might be critically important for patients with endocrine and metabolic disorders.
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