Effects of pentobarbital on upper airway patency during sleep.
Effects of pentobarbital on upper airway patency during sleep.
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DOI：
10.1183/09031936.00153809
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Malhotra A
中科院分区：
文献类型：
--
作者：
Eikermann M;Eckert DJ;Chamberlin NL;Jordan AS;Zaremba S;Smith S;Rosow C;Malhotra A
我们假设，戊巴比妥将改善上气道力学的基础上增加的潜伏期唤醒和振幅的相位颏舌肌肌电图（EMG），并在主动上气道临界关闭压（Pcrit）的下降。12名健康受试者在双盲交叉方案中接受戊巴比妥（100 mg）或安慰剂。在清醒期间，我们测量了颏舌肌对负压脉冲的反射反应。在睡眠期间，二氧化碳被吹入吸入的空气中。然后逐步降低气道压力，直到从睡眠中唤醒。睡眠期间基础呼吸：给予戊巴比妥的志愿者流速较低;潮气末CO2浓度和上气道阻力较高; Pcrit未受影响（戊巴比妥平均值±sd-11.7 × 4.5 vs安慰剂-10.25 × 3.6 cmH 2 O; p=0.11）。戊巴比妥增加了觉醒时间（297± 63 s对232±67 s; p<0.05），此时颏舌肌肌电图的最大值较高（6.2±4.8%对3.1±3%; p<0.05），CO2水平也较高。与安慰剂相比，戊巴比妥给药后CO2给药后颏舌肌EMG的增加更大。戊巴比妥不影响颏舌肌负压反射。戊巴比妥增加唤醒时间并刺激颏舌肌活动，但它也增加睡眠期间的上呼吸道阻力。
We hypothesised that pentobarbital would improve upper airway mechanics based on an increase in latency to arousal and amplitude of the phasic genioglossus electromyogram (EMG), and a decrease in the active upper airway critical closing pressure (Pcrit). 12 healthy subjects received pentobarbital (100 mg) or placebo in a double-blind, crossover protocol. During wakefulness, we measured the genioglossus reflex response to negative pressure pulses. During sleep, carbon dioxide was insufflated into the inspired air. Airway pressure was then decreased in a stepwise fashion until arousal from sleep. With basal breathing during sleep: flow rate was lower in volunteers given pentobarbital; end-tidal CO2 concentration and upper airway resistance were greater; and Pcrit was unaffected (pentobarbital mean±sd -11.7±4.5 versus placebo -10.25±3.6 cmH2O; p=0.11). Pentobarbital increased the time to arousal (297±63s versus 232±67 s; p<0.05), at which time phasic genioglossus EMG was higher (6.2±4.8% maximal versus 3.1±3%; p<0.05) as were CO2 levels. The increase in genioglossus EMG after CO2 administration was greater after pentobarbital versus placebo. Pentobarbital did not affect the genioglossus negative-pressure reflex. Pentobarbital increases the time to arousal and stimulates genioglossus muscle activity, but it also increases upper airway resistance during sleep.
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DOI：
10.1164/rccm.200404-552oc
发表时间：
2005-07-01
影响因子：
24.7
作者：
Heinzer, RC;Stanchina, ML;White, DP
通讯作者：
White, DP
影响因子：
3.3
作者：
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DOI：
10.1164/ajrccm.151.2.7842205
发表时间：
1995-02-01
影响因子：
24.7
作者：
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通讯作者：
LIGHT, RW
影响因子：
8.8
作者：
Eikermann M;Fassbender P;Zaremba S;Jordan AS;Rosow C;Malhotra A;Chamberlin NL
通讯作者：
Chamberlin NL
影响因子：
8.8
作者：
Herbstreit, Frank;Peters, Juergen;Eikermann, Matthias
通讯作者：
Eikermann, Matthias