Associations of VEGF Polymorphisms With Retinopathy of Prematurity.
Associations of VEGF Polymorphisms With Retinopathy of Prematurity.
复制标题
DOI：
10.1167/iovs.64.7.11
复制
发表时间：
2023-06-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究探讨了血管内皮生长因子（VEGF）多态性与早产儿视网膜病变（ROP）风险之间的关系。包括2009年至2018年期间任何时间早产的婴儿。采用实时荧光定量PCR技术分析5个VEGF单核苷酸多态性（snp）。应用多因素logistic回归模型分析VEGF多态性与ROP易感性、严重程度和早期临床病理特征之间的关系。共纳入334例患者，分为三组：无ROP、轻度ROP（即不需要治疗的ROP）和重度ROP（即需要治疗的ROP）。在女性ROP患者中，VEGF rs3025035 CT（3.231倍，95%可信区间[CI]， 1.238 ~ 8.431）和CT与TT基因型合并（2.643倍，95% CI, 1.056 ~ 6.619）发生严重ROP的风险明显高于野生型。带有VEGF rs3025010 C （TC + CC）等位基因的ROP女性婴儿发生ROP分期≥3期的风险低于带有TT纯合子的ROP女性婴儿（优势比[OR] = 0.406; 95% CI, 0.165-0.999）。具有VEGF rs10434 A等位基因（GA + AA）的ROP患者发生坏死性小肠结肠炎的风险较高（OR = 2.750; 95% CI, 1.119-6.759），支气管肺发育不良的风险较GG纯合子患者低（OR = 0.390; 95% CI, 0.173-0.877）。VEGF多态性对男性和女性婴儿ROP风险的影响不同。在女婴中，带有T等位基因的VEGF rs3025035可能预测ROP的严重程度，而带有C等位基因的VEGF rs3025010可能对严重ROP有保护作用。
This study investigated the associations between vascular endothelial growth factor (VEGF) polymorphisms and retinopathy of prematurity (ROP) risk. Infants born prematurely at any time from 2009 to 2018 were included. Five single-nucleotide polymorphisms (SNPs) of VEGF were analyzed using real-time PCR in all infants. Multivariate logistic regression was applied to model the associations between VEGF polymorphisms and ROP susceptibility, severity, and premature clinicopathologic characteristics. A total of 334 patients were included and categorized into three groups: those without ROP, those with mild ROP (i.e., ROP not requiring treatment), and those with severe ROP (i.e., ROP for whom treatment was indicated). Among the female patients with ROP, those with VEGF rs3025035 CT (3.231-fold; 95% confidence interval [CI], 1.238–8.431) and a combination of CT and TT genotypes (2.643-fold; 95% CI, 1.056–6.619) exhibited significantly higher risks of severe ROP compared with those with wild-type genotypes. Female ROP infants with VEGF rs3025010 C (TC + CC) alleles had a lower risk of ROP stage ≥3 (odds ratio [OR] = 0.406; 95% CI, 0.165–0.999) than those with TT homozygotes. ROP patients with the VEGF rs10434 A allele (GA + AA) exhibited higher risks of necrotizing enterocolitis (OR = 2.750; 95% CI, 1.119–6.759) and lower risk of bronchopulmonary dysplasia (OR = 0.390; 95% CI, 0.173–0.877) than those with GG homozygotes did. VEGF polymorphisms affect ROP risks differently in male and female infants. In female infants, VEGF rs3025035 with T alleles may predict ROP severity, and VEGF rs3025010 with C alleles may protect against severe ROP.
登录
查看更多内容
影响因子：
5.1
作者：
Kim SJ;Port AD;Swan R;Campbell JP;Chan RVP;Chiang MF
通讯作者：
Chiang MF
影响因子：
4.6
作者：
Fujioka K;Shibata A;Yokota T;Koda T;Nagasaka M;Yagi M;Takeshima Y;Yamada H;Iijima K;Morioka I
通讯作者：
Morioka I
影响因子：
13.7
作者：
Abedi, Farshad;Wickremasinghe, Sanjeewa;Guymer, Robyn H.
通讯作者：
Guymer, Robyn H.
影响因子：
3.7
作者：
Lundgren, Pia;Kistner, Anna;Lofqvist, Chatarina
通讯作者：
Lofqvist, Chatarina
影响因子：
--
作者：
Pierce, EA;Foley, ED;Smith, LEH
通讯作者：
Smith, LEH