Retinopathy of prematurity: a review of risk factors and their clinical significance.

Retinopathy of prematurity: a review of risk factors and their clinical significance.
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DOI:
10.1016/j.survophthal.2018.04.002
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发表时间:
2018-09
影响因子:
5.1
通讯作者:
Chiang MF
Chiang MF
中科院分区:
医学2区
文献类型:
--
作者:
Kim SJ;Port AD;Swan R;Campbell JP;Chan RVP;Chiang MF

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早产儿视网膜病变(ROP)是一种影响早产儿的视网膜血管增生性疾病。尽管新生儿护理和管理指南有所改进,但ROP仍然是全球儿童失明的主要原因。目前的筛查指南主要基于两个危险因素:出生体重和胎龄;然而,许多研究人员提出了其他危险因素,包括母亲因素、产前和围产期因素、人口统计学、医疗干预、早产儿合并症、营养和遗传因素。我们回顾了有关各种可能的ROP风险因素的现有文献。尽管有相互矛盾的报道,而且不同人群的风险可能不同,但了解ROP的危险因素对于开发预测模型、深入了解视网膜血管疾病和早产儿疾病的病理生理学以及确定ROP未来的管理和研究方向是至关重要的。
Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors. We review the existing literature addressing various possible ROP risk factors. Although there have been contradictory reports, and the risk may vary between different populations, understanding ROP risk factors is essential to develop predictive models, to gain insights into pathophysiology of retinal vascular diseases and diseases of prematurity, and to determine future directions in management and research in ROP.
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