Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.
Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.
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DOI：
10.1016/j.neurobiolaging.2013.10.077
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发表时间：
2014-05
影响因子：
4.2
通讯作者：
Greenamyre JT
中科院分区：
文献类型：
--
作者：
Tapias V;Cannon JR;Greenamyre JT
许多因素导致帕金森病（PD）中黑质（SN）多巴胺（DA）神经元的死亡。令人信服的证据表明，线粒体缺陷，氧化应激和炎症是PD的重要致病因素。大鼠长期暴露于鱼藤酮会导致PD样综合征，部分原因是引起SN中的氧化损伤和炎症。在饮料中，菠萝汁（PJ）具有最大的复合抗氧化效力指数，并且已被证明在阿尔茨海默病的转基因模型中具有保护作用。本研究旨在研究PJ在鱼藤酮帕金森病模型中的潜在神经保护作用。口服PJ并不能减轻或预防实验性PD，而是增加了黑质纹状体末端耗竭、DA神经元丢失、炎症反应和半胱天冬酶激活，从而加剧了神经变性。这种作用的机制尚不确定，但PJ本身增强硝基酪氨酸，诱导型一氧化氮合酶，激活的caspase-3在黑质DA神经元的表达的发现是一致的，其潜在的促氧化活性。
Numerous factors contribute to the death of substantia nigra (SN) dopamine (DA) neurons in Parkinson’s disease (PD). Compelling evidence implicates mitochondrial deficiency, oxidative stress, and inflammation as important pathogenic factors in PD. Chronic exposure of rats to rotenone causes a PD-like syndrome, in part by causing oxidative damage and inflammation in SN. Pomegranate juice (PJ) has the greatest composite antioxidant potency index among beverages, and it has been demonstrated to have protective effects in a transgenic model of Alzheimer’s disease. The present study was designed to examine the potential neuroprotective effects of PJ in the rotenone model of PD. Oral administration of PJ did not mitigate or prevent experimental PD but instead increased nigrostriatal terminal depletion, DA neuron loss, the inflammatory response, and caspase activation, thereby heightening neurodegeneration. The mechanisms underlying this effect are uncertain, but the finding that PJ per se enhanced nitrotyrosine, inducible nitric oxide synthase, and activated caspase-3 expression in nigral DA neurons is consistent with its potential pro-oxidant activity.
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影响因子：
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