Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1β production from monocytes in humans.
Active Hexose Correlated Compound promotes T helper (Th) 17 and 1 cell responses via inducing IL-1β production from monocytes in humans.
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DOI：
10.1016/j.cellimm.2012.04.001
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发表时间：
2012-01
影响因子：
4.3
通讯作者：
Kang, Insoo
中科院分区：
文献类型：
--
作者：
Lee, Won-Woo;Lee, Naeun;Fujii, Hajime;Kang, Insoo
辅助性T细胞(Th)的分化与细胞因子环境密切相关。先天免疫的单核细胞产生IL-1β，可影响Th17和Th1细胞的发育，而Th1细胞主要产生IL-17和干扰素-γ。微生物、农作物和蘑菇中的低聚糖可以刺激天然免疫细胞。活性己糖相关化合物是从担子菌菌丝体中提取的一种含有大量低聚糖的天然提取物。据报道，这种化合物可以调节对病原体的免疫反应，尽管这种作用的机制在很大程度上尚不清楚。在此，我们发现人肝细胞癌可以诱导人单核细胞产生高水平的IL-1β。此外，经肝癌处理的单核细胞可增加自体CD_4~+T细胞产生IL-17和干扰素-γ，这一作用可被IL-1受体拮抗剂阻断。这些发现为AHCC等食物补充剂如何通过调节单核细胞和Th细胞来提高人类免疫力提供了新的见解。
The differentiation of T helper (Th) cells is critically dependent on cytokine milieu. The innate immune monocytes produce IL-1β which can affect the development of Th17 and Th1 cells that predominantly produce IL-17 and IFN-γ, respectively. Oligosaccharides from microorganisms, crops and mushrooms can stimulate innate immune cells. Active Hexose Correlated Compound (AHCC) that contains a large amount of oligosaccharides is a natural extract prepared from the mycelium of the edible Basidiomycete fungus. This compound is reported to modulate immune responses against pathogens although the mechanisms for this effect are largely unknown. Here we show that AHCC could induce high levels of IL-1β production from human monocytes. Furthermore, AHCC-treated monocytes increased the production of IL-17 and IFN-γ from autologous CD4+ T cells, which was blocked by adding IL-1 receptor antagonist. These finding provide new insight into how food supplements like AHCC could enhance human immunity by modulating monocytes and Th cells.
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