Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population.
Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population.
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血清丙氨酸转氨酶/天冬氨酸转氨酶比值是中国人群胰岛素抵抗的最佳标志之一。
DOI：
10.1186/s12986-017-0219-x
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发表时间：
2017
影响因子：
4.5
通讯作者：
Lu Y
中科院分区：
文献类型：
--
作者：
Zhao L;Cheng J;Chen Y;Li Q;Han B;Chen Y;Xia F;Chen C;Lin D;Yu X;Wang N;Lu Y
据报道，丙氨酸氨基转移酶（ALT）/天冬氨酸氨基转移酶（AST）比值与胰岛素抵抗（IR）相关。然而，很少有研究探讨ALT/AST比值与中国人群IR之间的关系。在此，我们旨在探讨ALT/AST比值是否与按腰围（WC）分类的中国人群中的IR相关，如果相关，相关程度如何。我们的数据来自SPECT-China研究，这是一项关于2014年至2015年华东地区代谢性疾病患病率和危险因素的横断面调查。本研究共纳入8398名年龄为52.16 ± 13.16（平均值±标准差）岁的参与者。测量人体测量学指标、生化指标和临床特征。IR定义为胰岛素抵抗稳态模型评估的上四分位数（HOMA-IR > 1.6），中心性肥胖定义为男性WC ≥90 cm或女性WC ≥80 cm。进行线性回归和受试者工作特征曲线分析。ALT/AST比值与HOMA-IR显著相关，（r = 0.284，B = 0.509，95%可信区间（CI）：0.459-0.559，P < 0.001）和中心性肥胖者（r = 0.372，B = 0.607，95%CI：0.532-0.683，P < 0.001）。ALT/AST比值是IR的最佳标志物之一，非中心性肥胖受试者的曲线下面积（AUC）值为0.66（0.64-0.68），中心性肥胖受试者为0.68（0.66-0.70）。在IR的预测模型中，加入ALT/AST比值后，两组非中心性肥胖患者的AUC均显著增加[AUC 95%CI 0.69（0.67-0.71）vs 0.72（0.70-0.74），P<0.001]和中心性肥胖[AUC 95%CI 0.69（0.67-0.71）vs 0.73（0.72-0.75），P<0.001]受试者。ALT/AST比值用于识别IR的最佳截止点在非中心性肥胖人群中为0.80，在中心性肥胖人群中为0.78。ALT/AST比值可能是中国人群IR的最佳指标之一。ALT/AST比值是否应被视为中国人群中代谢综合征的额外组成部分，需要进一步研究。本文的在线版本（10.1186/s12986-017-0219-x）包含补充材料，可供授权用户使用。
The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio and IR in the Chinese population. Here, we aimed to explore whether the ALT/AST ratio is associated and, if so, to what extent, with IR in the Chinese population as categorized by waist circumference (WC). Our data were obtained from the SPECT-China study, a cross-sectional survey on the prevalence of metabolic diseases and risk factors in East China from 2014 to 2015. A total of 8398 participants aged 52.16 ± 13.16 (mean ± standard deviation) years were included in this study. Anthropometric indices, biochemical parameters and clinical characteristics were measured. IR was defined as the top quartile of the homeostasis model assessment of insulin resistance (HOMA-IR > 1.6), and central obesity was defined as a WC ≥90 cm in males or ≥80 cm in females. Linear regression and receiver operating characteristic curve analyses were conducted. The ALT/AST ratio was significantly correlated and associated with HOMA-IR in both non-centrally obese (r = 0.284, B = 0.509, 95% confidence interval (CI): 0.459–0.559, P < 0.001) and centrally obese subjects (r = 0.372, B = 0.607, 95%CI: 0.532–0.683, P < 0.001) after adjusting for potential confounders. The ALT/AST ratio was one of the best markers of IR, with areas under the curve (AUC) values of 0.66 (0.64–0.68) in non-centrally and 0.68 (0.66–0.70) in centrally obese subjects. In the prediction model for IR, the AUCs were significantly augmented after adding the ALT/AST ratio in both non-centrally obese [AUC 95%CI 0.69(0.67–0.71) vs 0.72(0.70–0.74), P<0.001] and central obese [AUC 95%CI 0.69(0.67–0.71) vs 0.73(0.72–0.75), P<0.001] subjects. The optimal cut-off points of the ALT/AST ratio for identifying IR were 0.80 in non-centrally obese people and 0.78 in centrally obese people, respectively. The ALT/AST ratio may be one of the best markers for IR in the Chinese population. Whether the ALT/AST ratio should be regarded as an additional metabolic syndrome component in the Chinese population warrants further investigation. The online version of this article (10.1186/s12986-017-0219-x) contains supplementary material, which is available to authorized users.
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4.8
作者：
Yin J;Li M;Xu L;Wang Y;Cheng H;Zhao X;Mi J
通讯作者：
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