Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study.
Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study.
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DOI：
10.1186/1472-6823-13-47
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发表时间：
2013-10-16
影响因子：
2.7
通讯作者：
Quintela AG
中科院分区：
文献类型：
--
作者：
Gayoso-Diz P;Otero-González A;Rodriguez-Alvarez MX;Gude F;García F;De Francisco A;Quintela AG
胰岛素抵抗与代谢和血流动力学改变以及较高的心脏代谢风险有关。用于定义胰岛素抵抗的胰岛素抵抗阈值稳态模型评估 (HOMA-IR) 水平存在很大差异。本研究的目的是描述年龄和性别对 HOMA-IR 最佳截止值估计的影响，以识别一般成年人群中具有较高心脏代谢风险的受试者。它包括随机西班牙人口样本中的 2459 名成年人（范围为 20-92 岁，58.4% 为女性）。作为心脏代谢风险的准确指标，使用了国际糖尿病联合会标准和成人治疗小组 III 标准的代谢综合征 (MetS)。分别分析了患有和不患有糖尿病的个体的年龄影响。 ROC 回归方法用于评估年龄对 HOMA-IR 在心脏代谢风险分类中表现的影响。在西班牙人口中，HOMA-IR 的阈值从使用 90% 标准的 3.46 下降到考虑 MetS 成分的 2.05。在非糖尿病女性中，但在男性中没有，我们发现年龄对 HOMA-IR 准确性有显着的非线性影响。在非糖尿病男性中，临界值为 1.85。所有值均位于西班牙成年人 HOMA-IR 水平的 70% 至 75% 之间。考虑心脏代谢风险来建立 HOMA-IR 的分界点，定义胰岛素抵抗，而不是使用人口分布的百分位，将增加其在识别那些存在多种代谢风险因素导致代谢和心血管风险增加的患者方面的临床实用性。非糖尿病女性的阈值水平必须根据年龄进行修改。
Insulin resistance has been associated with metabolic and hemodynamic alterations and higher cardio metabolic risk. There is great variability in the threshold homeostasis model assessment of insulin resistance (HOMA-IR) levels to define insulin resistance. The purpose of this study was to describe the influence of age and gender in the estimation of HOMA-IR optimal cut-off values to identify subjects with higher cardio metabolic risk in a general adult population. It included 2459 adults (range 20–92 years, 58.4% women) in a random Spanish population sample. As an accurate indicator of cardio metabolic risk, Metabolic Syndrome (MetS), both by International Diabetes Federation criteria and by Adult Treatment Panel III criteria, were used. The effect of age was analyzed in individuals with and without diabetes mellitus separately. ROC regression methodology was used to evaluate the effect of age on HOMA-IR performance in classifying cardio metabolic risk. In Spanish population the threshold value of HOMA-IR drops from 3.46 using 90th percentile criteria to 2.05 taking into account of MetS components. In non-diabetic women, but no in men, we found a significant non-linear effect of age on the accuracy of HOMA-IR. In non-diabetic men, the cut-off values were 1.85. All values are between 70th-75th percentiles of HOMA-IR levels in adult Spanish population. The consideration of the cardio metabolic risk to establish the cut-off points of HOMA-IR, to define insulin resistance instead of using a percentile of the population distribution, would increase its clinical utility in identifying those patients in whom the presence of multiple metabolic risk factors imparts an increased metabolic and cardiovascular risk. The threshold levels must be modified by age in non-diabetic women.
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影响因子：
5.1
作者：
Do, Hau D.;Lohsoonthorn, Vitool;Jiamjarasrangsi, Wiroj;Lertmaharit, Somrat;Williams, Michelle A.
通讯作者：
Williams, Michelle A.
影响因子：
16.2
作者：
Bertoni, Alain G.;Wong, Nathan D.;Szklo, Moyses
通讯作者：
Szklo, Moyses
影响因子：
16.2
作者：
Marques-Vidal, P;Mazoyer, E;Ferrières, J
通讯作者：
Ferrières, J
影响因子：
37.8
作者：
Eckel, Robert H.;Kahn, Richard;Rizza, Robert A.
通讯作者：
Rizza, Robert A.
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.