The effect of low-magnitude, high-frequency vibration on poly(ethylene glycol)-microencapsulated mesenchymal stem cells.
The effect of low-magnitude, high-frequency vibration on poly(ethylene glycol)-microencapsulated mesenchymal stem cells.
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DOI：
10.1177/2041731418800101
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发表时间：
2018-01
影响因子：
8.2
通讯作者：
Olabisi RM
中科院分区：
文献类型：
--
作者：
Mehta S;McClarren B;Aijaz A;Chalaby R;Cook-Chennault K;Olabisi RM
当间充质干细胞在特定类型的三维环境中培养时，低幅度、高频率的振动刺激了这些细胞的成骨。然而，成骨的结果与一些报道显示根本没有振动的影响相矛盾。大量使用三维脚手架的振动研究使用来自自然来源的脚手架。由于这些自然来源潜在地具有内在的生化和微结构线索，我们探索了当间充质干细胞被包裹在聚乙二醇二丙烯酸酯微球中时，在低、中、高加速下的低幅度、高频振动的影响。低和中等加速促进间充质干细胞的成骨，而高加速则抑制其成骨。这些研究表明，仅振动的隔离效应就能诱导成骨。
Low-magnitude, high-frequency vibration has stimulated osteogenesis in mesenchymal stem cells when these cells were cultured in certain types of three-dimensional environments. However, results of osteogenesis are conflicting with some reports showing no effect of vibration at all. A large number of vibration studies using three-dimensional scaffolds employ scaffolds derived from natural sources. Since these natural sources potentially have inherent biochemical and microarchitectural cues, we explored the effect of low-magnitude, high-frequency vibration at low, medium, and high accelerations when mesenchymal stem cells were encapsulated in poly(ethylene glycol) diacrylate microspheres. Low and medium accelerations enhanced osteogenesis in mesenchymal stem cells while high accelerations inhibited it. These studies demonstrate that the isolated effect of vibration alone induces osteogenesis.
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影响因子：
2.8
作者：
Lau, Esther;Lee, W. David;Li, Jason;Xiao, Andrew;Davies, John E.;Wu, Qianhong;Wang, Liyun;You, Lidan
通讯作者：
You, Lidan
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
2.9
作者：
Chen, Yi-Jane;Huang, Chien-Hsun;Young, Tai-Horng
通讯作者：
Young, Tai-Horng
DOI：
10.1073/pnas.0903269107
发表时间：
2010-03-16
影响因子：
11.1
作者：
Kilian, Kristopher A.;Bugarija, Branimir;Mrksich, Milan
通讯作者：
Mrksich, Milan
影响因子：
4.1
作者：
Lau, Esther;Al-Dujaili, Saja;Guenther, Axel;Liu, Dawei;Wang, Liyun;You, Lidan
通讯作者：
You, Lidan