Insulin-like growth factor-1 receptor and phosphorylated AKT-serine 473 expression in 132 resected thymomas and thymic carcinomas.
Insulin-like growth factor-1 receptor and phosphorylated AKT-serine 473 expression in 132 resected thymomas and thymic carcinomas.
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DOI：
10.1002/cncr.25367
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发表时间：
2010-10-15
期刊：
影响因子：
6.2
通讯作者：
Giaccone, Giuseppe
中科院分区：
文献类型：
--
作者：
Zucali, Paolo A.;Petrini, Iacopo;Lorenzi, Elena;Merino, Maria;Cao, Liang;Di Tommaso, Luca;Lee, Hye Seung;Incarbone, Matteo;Walter, Beatriz A.;Simonelli, Matteo;Roncalli, Massimo;Santoro, Armando;Giaccone, Giuseppe
Thymic malignancies are rare tumors. The IGF-1/IGF-1R system is involved in the development of the thymus. IGF-1R expression in thymic epithelial malignancies is unknown. We investigated the expression of insulin-like growth factor 1 receptor (IGF-1R) and phospho-AKT Ser-473 (p-AKT) by immunohistochemistry and the clinicopathological correlations in a retrospective single institution surgical series of 132 thymic epithelial malignancies. Earlier stages, less aggressive histological types, and complete resections were significant positive prognostic factors for disease-related survival and progression-free survival, and female gender was a better prognostic factor for disease-related survival. IGF-1R and p-AKT proteins were expressed in 20% and 36% of thymic tumors, respectively. They were both more commonly expressed in relapsed than in primary tumors, in more aggressive subtypes and more advanced stages. There was a trend for better survival and progression-free survival in IGF-1R or p-AKT expression negative cases in the whole series; considering the 91 primary tumors only, IGF1R expression was associated with worse progression-free survival (p<0.001). This retrospective analysis demonstrates stage, histology, gender and resection type as major prognostic factors. The expression of IGF-1R and p-AKT in thymic tumors suggests IGF-1R as a potential target for treatment.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
7.3
作者：
Pan, CC;Chen, PCH;Chiang, H
通讯作者：
Chiang, H
DOI：
10.1097/jto.0b013e3181b6be57
发表时间：
2009-10
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Giaccone G;Rajan A;Ruijter R;Smit E;van Groeningen C;Hogendoorn PC
通讯作者：
Hogendoorn PC
影响因子：
6.2
作者：
Okumura, M;Ohta, M;Masaoka, A
通讯作者：
Masaoka, A
DOI：
10.1053/ejso.2001.1197
发表时间：
2001-11-01
期刊：
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
影响因子：
--
作者：
Lucchi, M;Mussi, A;Angeletti, CA
通讯作者：
Angeletti, CA