A Case of Papuloerythroderma Successfully Treated with Dupilumab.

A Case of Papuloerythroderma Successfully Treated with Dupilumab.
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DOI:
10.1159/000524716
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发表时间:
2022-05
影响因子:
0.9
通讯作者:
--
中科院分区:
其他
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--
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丘疹性红皮病是一种红皮病,其特征在于腹壁上的致密铺路石状丘疹和擦烂的未受累皮肤的组成,并且通常是顽固性的并伴有瘙痒。局部或口服皮质类固醇是治疗措施,但有时需要免疫抑制药物。在此,我们报告了一例使用dupilumab治疗的丘疹性红皮病病例,dupilumab是一种针对IL-4和IL-13受体的白细胞介素-4受体亚基α(IL-4 R α)的完全人源化免疫球蛋白单克隆抗体,具有快速和显著的改善。Dupilumab是治疗难治性丘疹性红皮病的治疗选择之一。
Papuloerythroderma is an erythroderma characterized by the composition of dense paving stone shape papules and intertriginous uninvolved skin on the abdominal wall and is often intractable and accompanied by itching. Topical or oral corticosteroids are treatment measures, but immunosuppressive drugs are sometimes required. Herein, we report a case of papuloerythroderma treated with dupilumab, a completely humanized immunoglobulin monoclonal antibody against interleukin-4 receptor subunit α (IL-4Rα) of IL-4 and IL-13 receptors, with rapid and marked improvement. Dupilumab is one of the treatment options to treat refractory papuloerythroderma.
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发表时间: 1997-06-06
影响因子: 4.8
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Imai, T;Baba, M;Yoshie, O
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