Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles.
Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles.
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DOI：
10.1016/j.bmcl.2012.11.015
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发表时间：
2013-01-15
影响因子：
2.7
通讯作者：
Berkman, Clifford E.
中科院分区：
文献类型：
--
作者：
Kasten, Benjamin B.;Liu, Tiancheng;Nedrow-Byers, Jessie R.;Benny, Paul D.;Berkman, Clifford E.
Prostate-specific membrane antigen (PSMA) is a notable biomarker for diagnostic and therapeutic applications in prostate cancer. Gold nanoparticles (AuNPs) provide an attractive nanomaterial platform for combining a variety of targeting, imaging, and cytotoxic agents into a unified device for biomedical research. In this study, we present the generation and evaluation of the first AuNP system functionalized with a small molecule phosphoramidate peptidomimetic inhibitor for the targeted delivery to PSMA-expressing prostate cancer cells. The general approach involved the conjugation of streptavidin-coated AuNPs with a biotin-linked PSMA inhibitor (CTT54) to generate PSMA-targeted AuNPs. In vitro evaluations of these targeted AuNPs were conducted to determine PSMA-mediated and time-dependent binding to PSMA-positive LNCaP cells. The PSMA-targeted AuNPs exhibited significantly higher and selective binding to LNCaP cells compared to control non-targeted AuNPs, thus demonstrating the feasibility of this approach.
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影响因子：
3.9
作者：
CHAIET, L;WOLF, FJ
通讯作者：
WOLF, FJ
DOI：
10.1073/pnas.86.7.2190
发表时间：
1989-04-01
影响因子：
11.1
作者：
HENDRICKSON, WA;PAHLER, A;PHIZACKERLEY, RP
通讯作者：
PHIZACKERLEY, RP
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影响因子：
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作者：
Chen, Li Qiang;Xiao, Sai Jin;Huang, Cheng Zhi
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影响因子：
3.3
作者：
Artemov, D;Mori, N;Bhujwalla, ZM
通讯作者：
Bhujwalla, ZM
影响因子：
17.1
作者：
Chen, Zhihang;Penet, Marie-France;Nimmagadda, Sridhar;Li, Cong;Banerjee, Sangeeta R.;Winnard, Paul T., Jr.;Artemov, Dmitri;Glunde, Kristine;Pomper, Martin G.;Bhujwalla, Zaver M.
通讯作者：
Bhujwalla, Zaver M.