Dynamics of the infant gut microbiota in the first 18 months of life: the impact of maternal HIV infection and breastfeeding.
Dynamics of the infant gut microbiota in the first 18 months of life: the impact of maternal HIV infection and breastfeeding.
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婴儿出生后 18 个月内肠道微生物群的动态：母亲 HIV 感染和母乳喂养的影响。
DOI：
10.1186/s40168-022-01230-1
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发表时间：
2022-04-12
期刊：
影响因子：
15.5
通讯作者：
Charurat M
中科院分区：
文献类型：
--
作者：
Grant-Beurmann S;Jumare J;Ndembi N;Matthew O;Shutt A;Omoigberale A;Martin OA;Fraser CM;Charurat M
感染艾滋病毒的母亲在怀孕和母乳喂养期间获得抗逆转录病毒治疗（ART）可以减少围产期和产后感染艾滋病毒的儿童，从而导致接触病毒但未感染的儿童数量增加（HEU）。与未接触艾滋病毒 (HUU) 的同龄人相比，HEU 婴儿儿童期感染和不良生长结果的可能性更高，死亡率也更高。在这项研究中，我们探讨了由 HIV 阳性和阴性母亲所生的 272 名尼日利亚婴儿在出生后 18 个月内肠道微生物群的潜在差异。根据 HIV 状况，母体阴道和肠道微生物群的分类组成没有显着差异，HUU 和 HEU 之间婴儿出生时肠道微生物群的组成相似。婴儿肠道微生物群的纵向分类组成和年龄别体重 z 分数 (WAZ) 根据母乳的获取情况而有所不同。在所有时间点，HEU 婴儿的 WAZ 总体均低于 HUU 婴儿。我们观察到产后 6 个月 HEU 婴儿中双歧杆菌的相对丰度显着降低。母乳成分也因时间点和艾滋病毒感染状况而异。抗逆转录病毒治疗药物拉米夫定和奈韦拉平以及犬尿氨酸在艾滋病毒母亲的母乳中含量明显更高。没有感染艾滋病毒的母亲的母乳中的替甘酰肉碱（C5）水平显着降低。感染艾滋病毒的母亲母乳中的抗逆转录病毒药物与长双歧杆菌相对丰度较低有关。在这项研究中，母亲 HIV 感染与 HEU 婴儿的不良生长结果相关，并且这些差异从出生起持续至少 18 个月，这是免疫和中枢神经系统发育的关键窗口。我们观察到双歧杆菌属的相对丰度。在产后前 6 个月内，所有 HEU 婴儿的肠道微生物群均显着降低，即使 HEU 婴儿接受母乳也是如此。在我们的 HEU 婴儿队列中，母乳喂养在产后最初几周是有益的；然而，母乳中的 ART 药物代谢物与双歧杆菌丰度较低有关。视频摘要 在线版本包含可在 10.1186/s40168-022-01230-1 获取的补充材料。
Access to antiretroviral therapy (ART) during pregnancy and breastfeeding for mothers with HIV has resulted in fewer children acquiring HIV peri- and postnatally, resulting in an increase in the number of children who are exposed to the virus but are not infected (HEU). HEU infants have an increased likelihood of childhood infections and adverse growth outcomes, as well as increased mortality compared to their HIV-unexposed (HUU) peers. We explored potential differences in the gut microbiota in a cohort of 272 Nigerian infants born to HIV-positive and negative mothers in this study during the first 18 months of life. The taxonomic composition of the maternal vaginal and gut microbiota showed no significant differences based on HIV status, and the composition of the infant gut microbiota at birth was similar between HUU and HEU. Longitudinal taxonomic composition of the infant gut microbiota and weight-for-age z-scores (WAZ) differed depending on access to breast milk. HEU infants displayed overall lower WAZ than HUU infants at all time points. We observed a significantly lower relative abundance of Bifidobacterium in HEU infants at 6 months postpartum. Breast milk composition also differed by time point and HIV infection status. The antiretroviral therapy drugs, lamivudine and nevirapine, as well as kynurenine, were significantly more abundant in the breast milk of mothers with HIV. Levels of tiglyl carnitine (C5) were significantly lower in the breast milk of mothers without HIV. ART drugs in the breast milk of mothers with HIV were associated with a lower relative abundance of Bifidobacterium longum. Maternal HIV infection was associated with adverse growth outcomes of HEU infants in this study, and these differences persist from birth through at least 18 months, which is a critical window for the development of the immune and central nervous systems. We observed that the relative abundance of Bifidobacterium spp. was significantly lower in the gut microbiota of all HEU infants over the first 6 months postpartum, even if HEU infants were receiving breast milk. Breastfeeding was of benefit in our HEU infant cohort in the first weeks postpartum; however, ART drug metabolites in breast milk were associated with a lower abundance of Bifidobacterium. Video abstract The online version contains supplementary material available at 10.1186/s40168-022-01230-1.
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影响因子：
8
作者：
Cohen, Cheryl;Moyes, Jocelyn;Madhi, Shabir A.
通讯作者：
Madhi, Shabir A.
影响因子：
15.5
作者：
Fadrosh DW;Ma B;Gajer P;Sengamalay N;Ott S;Brotman RM;Ravel J
通讯作者：
Ravel J
影响因子：
3.8
作者：
Brennan, Alana T.;Bonawitz, Rachael;Fox, Matthew P.
通讯作者：
Fox, Matthew P.
DOI：
10.1097/01.qai.0000188122.15493.0a
发表时间：
2006-04-01
影响因子：
3.6
作者：
Brahmbhatt, H;Kigozi, G;Gray, R
通讯作者：
Gray, R
影响因子：
3.8
作者：
Colebunders, R;Hodossy, B;Fransen, K
通讯作者：
Fransen, K