A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
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DOI：
10.1016/j.jaci.2012.10.002
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发表时间：
2013-04
影响因子：
14.2
通讯作者：
Williams, L. Keoki
中科院分区：
文献类型：
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作者：
Levin, Albert M.;Mathias, Rasika A.;Huang, Lili;Roth, Lindsey A.;Daley, Denise;Myers, Rachel A.;Himes, Blanca E.;Romieu, Isabelle;Yang, Mao;Eng, Celeste;Park, Julie E.;Zoratti, Karla;Gignoux, Christopher R.;Torgerson, Dara G.;Galanter, Joshua M.;Huntsman, Scott;Nguyen, Elizabeth A.;Becker, Allan B.;Chan-Yeung, Moira;Kozyrskyj, Anita L.;Kwok, Pui-Yan;Gilliland, Frank D.;Gauderman, W. James;Bleecker, Eugene R.;Raby, Benjamin A.;Meyers, Deborah A.;London, Stephanie J.;Martinez, Fernando D.;Weiss, Scott T.;Burchard, Esteban G.;Nicolae, Dan L.;Ober, Carole;Barnes, Kathleen C.;Williams, L. Keoki
免疫球蛋白E（IgE）既是过敏性炎症的标志物，也是其介导物。尽管有报道称不同种族人群的血清总IgE水平存在差异，但非裔美国人和拉丁裔人在总IgE的遗传学研究中并未得到充分体现。
为了确定血清总IgE水平的遗传预测因子。
我们使用了来自EVE哮喘遗传学联盟的4292名个体（2469名非裔美国人、1564名欧裔美国人和259名拉丁裔人）的全基因组关联（GWA）数据。按种族群体（即非裔美国人、拉丁裔和欧裔美国人）以及哮喘状况在每个队列中进行关联检验。对所得的P值进行荟萃分析，同时考虑样本量和效应方向。在另外6个由5767名个体组成的队列中，对荟萃分析中排名靠前的单核苷酸多态性（SNP）关联进行重新评估。
我们确定了10个独特的区域，在这些区域中，综合关联统计量与血清总IgE水平相关（P值<5.0×10⁻⁶），并且在两个或更多人群组中，次要等位基因频率≥5%。对应于HLA - DQB1的变异体rs9469220是在复制队列以及发现组和复制组联合评估时与血清总IgE水平关联最显著的SNP（P值分别为0.007和2.45×10⁻⁷）。此外，早期GWA研究的结果在当前的荟萃分析中也得到了验证。
这项荟萃分析独立地确定了HLA - DQB1附近的一个变异体是多个种族群体中血清总IgE的预测因子。这项研究还扩展并证实了早期针对非裔美国人和拉丁裔人的GWA分析结果。
Immunoglobulin E (IgE) is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino individuals have not been well represented in genetic studies of total IgE. To identify the genetic predictors of serum total IgE levels. We used genome wide association (GWA) data from 4,292 individuals (2,469 African Americans, 1,564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (i.e., African American, Latino, and European American) and asthma status. The resulting p-values were meta-analyzed accounting for sample size and direction of effect. Top single nucleotide polymorphism (SNP) associations from the meta-analysis were reassessed in six additional cohorts comprising 5,767 individuals. We identified 10 unique regions where the combined association statistic was associated with total serum IgE levels (P-value <5.0×10−6) and the minor allele frequency was ≥5% in two or more population groups. Variant rs9469220, corresponding to HLA-DQB1, was the most significantly associated SNP with serum total IgE levels when assessed in both the replication cohorts and the discovery and replication sets combined (P-value = 0.007 and 2.45×10−7, respectively). In addition, findings from earlier GWA studies were also validated in the current meta-analysis. This meta-analysis independently identified a variant near HLA-DQB1 as a predictor of total serum IgE in multiple race-ethnic groups. This study also extends and confirms the findings of earlier GWA analyses in African American and Latino individuals.
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影响因子：
14.2
作者：
Gergen, Peter J.;Arbes, Samuel J., Jr.;Calatroni, Agustin;Mitchell, Herman E.;Zeldin, Darryl C.
通讯作者：
Zeldin, Darryl C.
DOI：
10.1016/j.jaci.2011.09.029
发表时间：
2012-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Granada M;Wilk JB;Tuzova M;Strachan DP;Weidinger S;Albrecht E;Gieger C;Heinrich J;Himes BE;Hunninghake GM;Celedón JC;Weiss ST;Cruikshank WW;Farrer LA;Center DM;O'Connor GT
通讯作者：
O'Connor GT
DOI：
10.1164/rccm.200309-1293oc
发表时间：
2004-02-01
影响因子：
24.7
作者：
Burchard, EG;Avila, PC;Silverman, EK
通讯作者：
Silverman, EK
影响因子：
12.4
作者：
Kozyrskyj, A. L.;HayGlass, K. T.;Becker, A. B.
通讯作者：
Becker, A. B.
DOI：
10.1016/j.cct.2004.03.002
发表时间：
2004-06-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Guilbert, TW;Morgan, WJ;Martinez, FD
通讯作者：
Martinez, FD