Brain state-dependent alterations of corticostriatal synchronized oscillations in awake and anesthetized parkinsonian rats
Brain state-dependent alterations of corticostriatal synchronized oscillations in awake and anesthetized parkinsonian rats
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清醒和麻醉帕金森病大鼠皮质纹状体同步振荡的脑状态依赖性改变
DOI：
10.1016/j.brainres.2019.04.019
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发表时间：
2019-08
期刊：
影响因子：
2.9
通讯作者：
Jia Jun
中科院分区：
文献类型：
--
作者：
Jiang Xinxin;Yan Yitong;Wang Ke;Wei Jing;Su Wenting;Jia Jun
皮质-基底神经节回路中过度的β同步振荡是帕金森病（PD）疾病特异性运动症状的标志。皮层和基底节之间的功能连接受到麻醉的影响。然而，麻醉依赖的大脑状态和同步网络振荡的改变之间的相关性仍然不清楚。在这项研究中，局部场电位（LFPs）同时记录在运动皮层和纹状体的多巴胺完整和多巴胺耗尽偏侧帕金森病大鼠。左旋多巴和三种麻醉剂（乌拉坦，戊巴比妥，异氟烷）被用来评估不同的大脑状态下的神经活动的变化。在清醒状态下，6-OHDA损伤大鼠的皮层和纹状体之间的高β（25-40 Hz）振荡和相干性增强。乌拉坦麻醉的大鼠间歇性地表现出激活状态和慢波活动，而皮层和纹状体之间的增强的同步低β振荡仅在激活状态期间观察到，其表现出类似于清醒状态期间观察到的活动模式。值得注意的是，与6-OHDA损伤大鼠的觉醒相比，乌拉坦显著降低了激活状态期间的β峰频率。虽然戊巴比妥和异氟烷通常减少β振荡和6-OHDA损伤大鼠的皮质和纹状体之间的连贯性，他们表现出明显的影响，α带活动。此外，异氟烷以剂量依赖性方式调节爆发抑制。我们的数据支持同步高β振荡与PD的运动症状直接相关。麻醉状态以脑状态依赖的方式影响皮层和纹状体之间的过度同步振荡。
The exaggerated beta synchronized oscillation in the cortico-basal ganglia circuit is a hallmark of disease-specific motor symptoms in Parkinson’s disease (PD). The functional connectivity between the cortex and basal ganglia was influenced by anesthesia. However, the correlation between anesthesia-dependent brain states and the alterations of synchronized network oscillations remains unclear. In this study, local field potentials (LFPs) were simultaneously recorded in the motor cortex and striatum of dopamine-intact and dopamine-depleted hemiparkinsonian rats. Levodopa and three anesthetics (urethane, pentobarbital, and isoflurane) were utilized to assess the changes in neural activity under different brain states. Enhanced high beta (25–40 Hz) oscillations and coherence between the cortex and striatum were found under the wakefulness in 6-OHDA-lesioned rats. Urethane-anesthetized rats exhibited both the activated state and slow wave activity intermittently, while the enhanced synchronized low beta oscillations between the cortex and striatum were observed only during the activated state, which exhibiting a pattern of activity analogous to those observed during the awake state. Notably, urethane significantly reduced the beta peak frequency during the activated state compared to wakefulness in 6-OHDA-lesioned rats. Although both pentobarbital and isoflurane commonly reduced beta oscillations and coherence between the cortex and striatum in 6-OHDA-lesioned rats, they exhibited the distinct influence over the alpha band activity. In addition, isoflurane regulated the burst suppression in a dose-dependent manner. Our data support that synchronized high beta oscillations are directly related to the motor symptoms of PD. Anesthesia regimes influence the excessive synchronized oscillations between the cortex and striatum in a brain state-dependent manner.
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DOI：
10.1056/nejmra0808281
发表时间：
2010-12-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brown EN;Lydic R;Schiff ND
通讯作者：
Schiff ND
影响因子：
4.3
作者：
Moran RJ;Mallet N;Litvak V;Dolan RJ;Magill PJ;Friston KJ;Brown P
通讯作者：
Brown P
影响因子：
3.7
作者：
Nakhnikian A;Rebec GV;Grasse LM;Dwiel LL;Shimono M;Beggs JM
通讯作者：
Beggs JM
影响因子：
3.4
作者：
Hohlefeld, F. U.;Huchzermeyer, C.;Nikulin, V. V.
通讯作者：
Nikulin, V. V.
DOI：
10.1073/pnas.1517629112
发表时间：
2015-11-03
影响因子：
11.1
作者：
Feingold, Joseph;Gibson, Daniel J.;Graybiel, Ann M.
通讯作者：
Graybiel, Ann M.