Daily energy expenditure through the human life course.

Daily energy expenditure through the human life course.
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通过人类生活课程的每日能量消耗。

DOI:
10.1126/science.abe5017
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发表时间:
2021-08-13
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
IAEA DLW Database Consortium
IAEA DLW Database Consortium
中科院分区:
其他
文献类型:
--
作者:
Pontzer H;Yamada Y;Sagayama H;Ainslie PN;Andersen LF;Anderson LJ;Arab L;Baddou I;Bedu-Addo K;Blaak EE;Blanc S;Bonomi AG;Bouten CVC;Bovet P;Buchowski MS;Butte NF;Camps SG;Close GL;Cooper JA;Cooper R;Das SK;Dugas LR;Ekelund U;Entringer S;Forrester T;Fudge BW;Goris AH;Gurven M;Hambly C;El Hamdouchi A;Hoos MB;Hu S;Joonas N;Joosen AM;Katzmarzyk P;Kempen KP;Kimura M;Kraus WE;Kushner RF;Lambert EV;Leonard WR;Lessan N;Martin C;Medin AC;Meijer EP;Morehen JC;Morton JP;Neuhouser ML;Nicklas TA;Ojiambo RM;Pietiläinen KH;Pitsiladis YP;Plange-Rhule J;Plasqui G;Prentice RL;Rabinovich RA;Racette SB;Raichlen DA;Ravussin E;Reynolds RM;Roberts SB;Schuit AJ;Sjödin AM;Stice E;Urlacher SS;Valenti G;Van Etten LM;Van Mil EA;Wells JCK;Wilson G;Wood BM;Yanovski J;Yoshida T;Zhang X;Murphy-Alford AJ;Loechl C;Luke AH;Rood J;Schoeller DA;Westerterp KR;Wong WW;Speakman JR;IAEA DLW Database Consortium

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每日总能量消耗(“总消耗”,MJ/d)反映了每日能量需求,是人类健康和生理学的关键变量,但目前尚不清楚每日消耗在生命过程中如何变化。在这里,我们分析了一个大型的,全球多样化的数据库的总支出测量的双标记水的方法为男性和女性年龄8天至95岁。我们发现,总支出是密切相关的幂律的方式,并确定四个不同的代谢生命阶段的脂肪质量。新生儿(0- 1岁)的无脂肪体重调整日消耗量在1岁左右时迅速加速至成人值以上约46%,在整个儿童期和青春期(1-20岁)缓慢下降至20岁左右的成人水平,在成年期(20-60岁)甚至在妊娠期间保持稳定,在老年人(60岁以上)中下降。总支出的这些变化为人类发展和老龄化提供了新的视角,并应有助于制定整个生命周期的营养和健康战略。消耗随着年龄的增长而变化,四个不同的代谢生命阶段反映了行为,解剖学和组织代谢的变化。
Total daily energy expenditure (“total expenditure”, MJ/d) reflects daily energy needs and is a critical variable in human health and physiology, yet it is unclear how daily expenditure changes over the life course. Here, we analyze a large, globally diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 yr. We show that total expenditure is strongly related to fat free mass in a power-law manner and identify four distinct metabolic life stages. Fat free mass-adjusted daily expenditure accelerates rapidly in neonates (0-1yr) to ~46% above adult values at ~1 yr, declines slowly throughout childhood and adolescence (1-20 yr) to adult levels at ~20 yr, remains stable in adulthood (20-60 yr) even during pregnancy, and declines in older adults (60+ yr). These changes in total expenditure shed new light on human development and aging and should help shape nutrition and health strategies across the lifespan. Expenditure varies as we age, with four distinct metabolic life stages reflecting changes in behavior, anatomy, and tissue metabolism.
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