Daily energy expenditure through the human life course.
Daily energy expenditure through the human life course.
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通过人类生活课程的每日能量消耗。
DOI:
10.1126/science.abe5017
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发表时间:
2021-08-13
期刊:
影响因子:
--
通讯作者:
IAEA DLW Database Consortium
中科院分区:
文献类型:
--
作者:
Pontzer H;Yamada Y;Sagayama H;Ainslie PN;Andersen LF;Anderson LJ;Arab L;Baddou I;Bedu-Addo K;Blaak EE;Blanc S;Bonomi AG;Bouten CVC;Bovet P;Buchowski MS;Butte NF;Camps SG;Close GL;Cooper JA;Cooper R;Das SK;Dugas LR;Ekelund U;Entringer S;Forrester T;Fudge BW;Goris AH;Gurven M;Hambly C;El Hamdouchi A;Hoos MB;Hu S;Joonas N;Joosen AM;Katzmarzyk P;Kempen KP;Kimura M;Kraus WE;Kushner RF;Lambert EV;Leonard WR;Lessan N;Martin C;Medin AC;Meijer EP;Morehen JC;Morton JP;Neuhouser ML;Nicklas TA;Ojiambo RM;Pietiläinen KH;Pitsiladis YP;Plange-Rhule J;Plasqui G;Prentice RL;Rabinovich RA;Racette SB;Raichlen DA;Ravussin E;Reynolds RM;Roberts SB;Schuit AJ;Sjödin AM;Stice E;Urlacher SS;Valenti G;Van Etten LM;Van Mil EA;Wells JCK;Wilson G;Wood BM;Yanovski J;Yoshida T;Zhang X;Murphy-Alford AJ;Loechl C;Luke AH;Rood J;Schoeller DA;Westerterp KR;Wong WW;Speakman JR;IAEA DLW Database Consortium
Total daily energy expenditure (“total expenditure”, MJ/d) reflects daily energy needs and is a critical variable in human health and physiology, yet it is unclear how daily expenditure changes over the life course. Here, we analyze a large, globally diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 yr. We show that total expenditure is strongly related to fat free mass in a power-law manner and identify four distinct metabolic life stages. Fat free mass-adjusted daily expenditure accelerates rapidly in neonates (0-1yr) to ~46% above adult values at ~1 yr, declines slowly throughout childhood and adolescence (1-20 yr) to adult levels at ~20 yr, remains stable in adulthood (20-60 yr) even during pregnancy, and declines in older adults (60+ yr). These changes in total expenditure shed new light on human development and aging and should help shape nutrition and health strategies across the lifespan. Expenditure varies as we age, with four distinct metabolic life stages reflecting changes in behavior, anatomy, and tissue metabolism.
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影响因子:
7.1
作者:
Butte, NF
通讯作者:
Butte, NF
影响因子:
3.2
作者:
Henry, CJK
通讯作者:
Henry, CJK
影响因子:
3.7
作者:
Alderman H;Headey D
通讯作者:
Headey D
影响因子:
2.8
作者:
Aoyagi, Yukitoshi;Park, Sungjin;Shephard, Roy J
通讯作者:
Shephard, Roy J
影响因子:
3.7
作者:
Doherty A;Jackson D;Hammerla N;Plötz T;Olivier P;Granat MH;White T;van Hees VT;Trenell MI;Owen CG;Preece SJ;Gillions R;Sheard S;Peakman T;Brage S;Wareham NJ
通讯作者:
Wareham NJ