DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs.
DIANA-LncBase: experimentally verified and computationally predicted microRNA targets on long non-coding RNAs.
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Diana-LNCBASE：长期非编码RNA上经过实验验证和计算预测的microRNA靶标。
DOI：
10.1093/nar/gks1246
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发表时间：
2013-01
影响因子：
14.9
通讯作者：
Hatzigeorgiou AG
中科院分区：
文献类型：
--
作者：
Paraskevopoulou MD;Georgakilas G;Kostoulas N;Reczko M;Maragkakis M;Dalamagas TM;Hatzigeorgiou AG
近年来，长链非编码RNA（lncRNA）及其生理/病理意义成为研究领域的热点。随着实验数量的快速增加和转录单位被更好地注释，索引lncRNA特性和功能的数据库逐渐成为这一过程的重要工具。DIANA-LncBase（www.microrna.gr/LncBase）的目的是加强研究人员的尝试，并解开microRNA（miRNA）-lncRNA推定的功能相互作用。这项研究首次对lncRNAs上的miRNA靶点进行了全面的注释。DIANA-LncBase在人类和小鼠lncRNA上承载了实验验证和计算预测的全转录组miRNA识别元件（MRE）。所进行的分析包括整合大多数可用的lncRNA资源、相关的高通量HITS-CLIP和PAR-CLIP实验数据以及最先进的计算机模拟靶点预测。DIANA-LncBase中可用的实验支持条目对应于>5000个相互作用，而计算预测的相互作用超过1000万。DIANA-LncBase包含每个miRNA-lncRNA对的详细信息，例如外部链接，转录本基因组位置的图形图，结合位点的表示，lncRNA组织表达以及MRE保守性和预测评分。
Recently, the attention of the research community has been focused on long non-coding RNAs (lncRNAs) and their physiological/pathological implications. As the number of experiments increase in a rapid rate and transcriptional units are better annotated, databases indexing lncRNA properties and function gradually become essential tools to this process. Aim of DIANA-LncBase (www.microrna.gr/LncBase) is to reinforce researchers’ attempts and unravel microRNA (miRNA)–lncRNA putative functional interactions. This study provides, for the first time, a comprehensive annotation of miRNA targets on lncRNAs. DIANA-LncBase hosts transcriptome-wide experimentally verified and computationally predicted miRNA recognition elements (MREs) on human and mouse lncRNAs. The analysis performed includes an integration of most of the available lncRNA resources, relevant high-throughput HITS-CLIP and PAR-CLIP experimental data as well as state-of-the-art in silico target predictions. The experimentally supported entries available in DIANA-LncBase correspond to >5000 interactions, while the computationally predicted interactions exceed 10 million. DIANA-LncBase hosts detailed information for each miRNA–lncRNA pair, such as external links, graphic plots of transcripts’ genomic location, representation of the binding sites, lncRNA tissue expression as well as MREs conservation and prediction scores.
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影响因子：
37.3
作者：
Gibb EA;Brown CJ;Lam WL
通讯作者：
Lam WL
影响因子：
64.5
作者：
Huarte M;Guttman M;Feldser D;Garber M;Koziol MJ;Kenzelmann-Broz D;Khalil AM;Zuk O;Amit I;Rabani M;Attardi LD;Regev A;Lander ES;Jacks T;Rinn JL
通讯作者：
Rinn JL
影响因子：
14.9
作者：
Kozomara A;Griffiths-Jones S
通讯作者：
Griffiths-Jones S
影响因子：
7
作者：
Harrow J;Frankish A;Gonzalez JM;Tapanari E;Diekhans M;Kokocinski F;Aken BL;Barrell D;Zadissa A;Searle S;Barnes I;Bignell A;Boychenko V;Hunt T;Kay M;Mukherjee G;Rajan J;Despacio-Reyes G;Saunders G;Steward C;Harte R;Lin M;Howald C;Tanzer A;Derrien T;Chrast J;Walters N;Balasubramanian S;Pei B;Tress M;Rodriguez JM;Ezkurdia I;van Baren J;Brent M;Haussler D;Kellis M;Valencia A;Reymond A;Gerstein M;Guigó R;Hubbard TJ
通讯作者：
Hubbard TJ
影响因子：
64.5
作者：
Hafner M;Landthaler M;Burger L;Khorshid M;Hausser J;Berninger P;Rothballer A;Ascano M Jr;Jungkamp AC;Munschauer M;Ulrich A;Wardle GS;Dewell S;Zavolan M;Tuschl T
通讯作者：
Tuschl T