Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder.
Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder.
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DOI：
10.1016/j.bpsc.2022.10.009
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发表时间：
2023-09
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影响因子：
--
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中科院分区：
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--
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难治性抑郁症（TRD）是指重度抑郁症患者在两次或两次以上抗抑郁药物试验后仍未得到缓解。TRD是一种常见且高度衰弱的疾病，但其神经生物学基础仍然知之甚少。最近的神经影像学研究揭示了皮层连接梯度分离初级感觉运动区和高阶联想皮层。这一基本地形决定了皮质信息流，并受到精神疾病的影响。我们研究了TRD如何影响基于梯度的分层皮质组织。在这项次要研究中，我们分析了56名TRD患者和28名健康对照者的静息状态功能磁共振成像数据，这些数据来自正念干预。使用梯度提取工具，得出了脑功能网络内部和之间皮层梯度分散的基线测量值，跨组比较，并与网络拓扑的图理论测量相关联。在患者中，相关分析用于将皮质梯度离散度测量与基线和干预后的焦虑、抑郁和正念的临床测量相关联。TRD患者主要内在脑网络内皮层梯度弥散度降低。通过基于图论的网络拓扑测量，减少皮层梯度分散与网络程度增加相关。默认模式、控制和边缘网络节点之间较低的分散与基线水平相关的特质焦虑、抑郁和正念。患者的基线边缘网络离散度预测干预后24周的特质焦虑评分。我们的研究结果为TRD皮层梯度结构的广泛改变提供了初步支持，暗示跨模式和边缘网络在TRD患者的抑郁、焦虑和低正念中起着重要作用。
Treatment-resistant depression (TRD) refers to patients with major depressive disorder who do not remit after 2 or more antidepressant trials. TRD is common and highly debilitating, but its neurobiological basis remains poorly understood. Recent neuroimaging studies have revealed cortical connectivity gradients that dissociate primary sensorimotor areas from higher-order associative cortices. This fundamental topography determines cortical information flow and is affected by psychiatric disorders. We examined how TRD impacts gradient-based hierarchical cortical organization. In this secondary study, we analyzed resting-state functional magnetic resonance imaging data from a mindfulness-based intervention enrolling 56 patients with TRD and 28 healthy control subjects. Using gradient extraction tools, baseline measures of cortical gradient dispersion within and between functional brain networks were derived, compared across groups, and associated with graph theoretical measures of network topology. In patients, correlation analyses were used to associate measures of cortical gradient dispersion with clinical measures of anxiety, depression, and mindfulness at baseline and following the intervention. Cortical gradient dispersion was reduced within major intrinsic brain networks in patients with TRD. Reduced cortical gradient dispersion correlated with increased network degree assessed through graph theory–based measures of network topology. Lower dispersion among default mode, control, and limbic network nodes related to baseline levels of trait anxiety, depression, and mindfulness. Patients’ baseline limbic network dispersion predicted trait anxiety scores 24 weeks after the intervention. Our findings provide preliminary support for widespread alterations in cortical gradient architecture in TRD, implicating a significant role for transmodal and limbic networks in mediating depression, anxiety, and lower mindfulness in patients with TRD.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
25.8
作者：
Kaiser, Roselinde H.;Andrews-Hanna, Jessica R.;Wager, Tor D.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C
影响因子：
7.6
作者：
NOLENHOEKSEMA, S;MORROW, J
通讯作者：
MORROW, J
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.