Concentration-response function for ozone and daily mortality: results from five urban and five rural U.K. populations.
Concentration-response function for ozone and daily mortality: results from five urban and five rural U.K. populations.
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DOI：
10.1289/ehp.1104108
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发表时间：
2012-10
影响因子：
10.4
通讯作者：
Anderson HR
中科院分区：
文献类型：
--
作者：
Atkinson RW;Yu D;Armstrong BG;Pattenden S;Wilkinson P;Doherty RM;Heal MR;Anderson HR
背景：短期接触臭氧与每日死亡率增加有关。浓度-反应关系的形状（尤其是是否存在阈值）对于估计公共卫生影响至关重要。目的：我们调查了 1993 年至 2006 年间英国五个城市和五个农村地区每日臭氧与死亡率之间的浓度-响应关系。方法：我们使用泊松回归，控制季节性、温度和流感，研究每日最大 8 小时臭氧与每日全因死亡率之间的关联，假设全年和特定季节期间的线性、线性阈值和样条模型。我们检查了对颗粒物（仅限城市地区）和替代温度指标调整的敏感性。结果：在全年分析中，我们发现伦敦臭氧与全因死亡率之间浓度-反应关系阈值的明确证据为 65 µg/m3 [95% 置信区间 (CI)：58, 83]，但在其他城市或农村地区几乎没有证据表明存在阈值。城市和农村地区全因死亡率的综合线性效应估计相当：臭氧浓度每增加 10 µg/m3，死亡率分别为 0.48% (95% CI: 0.35, 0.60) 和 0.58% (95% CI: 0.36, 0.81)。季节性分析表明了夏季城市和农村地区臭氧影响的阈值。结论：我们的结果表明，应使用阈值和非阈值模型以及按季节分层的模型来估计整个环境臭氧范围内的健康影响。伦敦存在阈值效应但其他研究领域没有的证据需要进一步调查。农村地区暴露于臭氧对公共卫生的影响不容忽视。
Background: Short-term exposure to ozone has been associated with increased daily mortality. The shape of the concentration–response relationship—and, in particular, if there is a threshold—is critical for estimating public health impacts. Objective: We investigated the concentration–response relationship between daily ozone and mortality in five urban and five rural areas in the United Kingdom from 1993 to 2006. Methods: We used Poisson regression, controlling for seasonality, temperature, and influenza, to investigate associations between daily maximum 8-hr ozone and daily all-cause mortality, assuming linear, linear-threshold, and spline models for all-year and season-specific periods. We examined sensitivity to adjustment for particles (urban areas only) and alternative temperature metrics. Results: In all-year analyses, we found clear evidence for a threshold in the concentration–response relationship between ozone and all-cause mortality in London at 65 µg/m3 [95% confidence interval (CI): 58, 83] but little evidence of a threshold in other urban or rural areas. Combined linear effect estimates for all-cause mortality were comparable for urban and rural areas: 0.48% (95% CI: 0.35, 0.60) and 0.58% (95% CI: 0.36, 0.81) per 10-µg/m3 increase in ozone concentrations, respectively. Seasonal analyses suggested thresholds in both urban and rural areas for effects of ozone during summer months. Conclusions: Our results suggest that health impacts should be estimated across the whole ambient range of ozone using both threshold and nonthreshold models, and models stratified by season. Evidence of a threshold effect in London but not in other study areas requires further investigation. The public health impacts of exposure to ozone in rural areas should not be overlooked.
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影响因子：
10.4
作者：
Rückerl R;Greven S;Ljungman P;Aalto P;Antoniades C;Bellander T;Berglind N;Chrysohoou C;Forastiere F;Jacquemin B;von Klot S;Koenig W;Küchenhoff H;Lanki T;Pekkanen J;Perucci CA;Schneider A;Sunyer J;Peters A;AIRGENE Study Group
通讯作者：
AIRGENE Study Group
影响因子：
8.3
作者：
Kim, SY;Lee, JT;Kim, H
通讯作者：
Kim, H
影响因子：
3.8
作者：
Brauer, M;Brumm, J;Petkau, AJ
通讯作者：
Petkau, AJ
影响因子：
4.9
作者：
Pattenden, Sam;Armstrong, Ben;Wilkinson, Paul
通讯作者：
Wilkinson, Paul
DOI：
10.1111/j.1467-9876.2006.00554.x
发表时间：
2006-01-01
影响因子：
1.6
作者：
Farrington, C. P.;Whitaker, H. J.
通讯作者：
Whitaker, H. J.