MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
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MaTAR25 lncRNA调控Tensin1基因影响乳腺癌进展。
DOI：
10.1038/s41467-020-20207-y
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发表时间：
2020-12-22
影响因子：
16.6
通讯作者：
Spector DL
中科院分区：
文献类型：
--
作者：
Chang KC;Diermeier SD;Yu AT;Brine LD;Russo S;Bhatia S;Alsudani H;Kostroff K;Bhuiya T;Brogi E;Pappin DJ;Bennett CF;Rigo F;Spector DL
长链非编码RNA（lncRNA）基因的失调与多种癌症类型有关。在这里，我们报告乳腺肿瘤相关RNA 25（MaTAR 25），核富集和染色质相关的lncRNA，在乳腺肿瘤细胞增殖，迁移和侵袭中发挥作用，在体外和体内。MaTAR 25通过与富含嘌呤的元件结合蛋白B（PUR B）相互作用，并与主要下游靶基因Tensin 1（Tns 1）相关联来调节其反式表达。Tns 1蛋白产物是连接细胞外基质和肌动蛋白细胞骨架之间的信号传导的粘着斑的关键组分。MaTAR 25的敲除导致Tns 1的下调，从而导致肌动蛋白细胞骨架的重组，以及粘着斑和微绒毛的减少。我们将LINC 01271鉴定为MaTAR 25的人类直系同源物，重要的是，LINC 01271的表达增加与患者预后不良和转移相关。我们的研究结果表明，LINC 01271代表了改变乳腺癌进展的潜在治疗靶点。一组长链非编码RNA（lncRNA），即乳腺肿瘤相关RNA 1-30（MaTAR 1-30），在乳腺肿瘤细胞和正常乳腺上皮细胞之间差异表达。在这里，作者报告说，MaTAR 25通过调节Tensin 1基因的表达在乳腺癌细胞增殖，迁移和侵袭中发挥作用。
Misregulation of long non-coding RNA (lncRNA) genes has been linked to a wide variety of cancer types. Here we report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear enriched and chromatin associated lncRNA that plays a role in mammary tumor cell proliferation, migration, and invasion, both in vitro and in vivo. MaTAR25 functions by interacting with purine rich element binding protein B (PURB), and associating with a major downstream target gene Tensin1 (Tns1) to regulate its expression in trans. The Tns1 protein product is a critical component of focal adhesions linking signaling between the extracellular matrix and the actin cytoskeleton. Knockout of MaTAR25 results in down-regulation of Tns1 leading to a reorganization of the actin cytoskeleton, and a reduction of focal adhesions and microvilli. We identify LINC01271 as the human ortholog of MaTAR25, and importantly, increased expression of LINC01271 is associated with poor patient prognosis and metastasis. Our findings demonstrate that LINC01271 represents a potential therapeutic target to alter breast cancer progression. A group of long non-coding RNAs (lncRNAs), Mammary Tumor Associated RNAs 1-30 (MaTARs 1-30), are differentially expressed between mammary tumor cells and normal mammary epithelial cells. Here the authors report that MaTAR25 plays a role in breast cancer cell proliferation, migration and invasion by regulating the expression of the Tensin1 gene in trans.
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel
影响因子：
16
作者：
Heinz S;Benner C;Spann N;Bertolino E;Lin YC;Laslo P;Cheng JX;Murre C;Singh H;Glass CK
通讯作者：
Glass CK
影响因子：
7.5
作者：
Bergmann, Jan H.;Spector, David L.
通讯作者：
Spector, David L.