Long non-coding RNAs: modulators of nuclear structure and function.

Long non-coding RNAs: modulators of nuclear structure and function.
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DOI:
10.1016/j.ceb.2013.08.005
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发表时间:
2014-02
影响因子:
7.5
通讯作者:
Spector, David L.
Spector, David L.
中科院分区:
生物学2区
文献类型:
--
作者:
Bergmann, Jan H.;Spector, David L.

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长非编码(LNC)RNA是调节各种细胞过程的关键因子。在细胞核中,这些包括核亚结构的组织,染色质状态的改变,以及通过与效应蛋白的相互作用和对其活性的调节来调节基因的表达。总的来说,lncRNAs形成了有吸引力的模型的核心,解释了跨时间和空间的核结构和动态调节的各个方面。在这里,我们回顾了最近的研究,这些研究表征了这些分子的子集在调节和微调核态方面的分子功能。
Long non-coding (lnc)RNAs are emerging key factors in the regulation of various cellular processes. In the nucleus, these include the organization of nuclear sub-structures, the alteration of chromatin state, and the regulation of gene expression through the interaction with effector proteins and modulation of their activity. Collectively, lncRNAs form the core of attractive models explaining aspects of structural and dynamic regulation in the nucleus across time and space. Here we review recent studies that characterize the molecular function of a subset of these molecules in the regulation and fine-tuning of nuclear state.
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