Increased oxidative stress in patients with depression and its relationship to treatment.
Increased oxidative stress in patients with depression and its relationship to treatment.
复制标题
DOI：
10.1016/j.psychres.2012.10.018
复制
发表时间：
2013-04-30
影响因子：
11.3
通讯作者：
Salomon, Ronald M.
中科院分区：
文献类型：
--
作者：
Chung, Cecilia P.;Schmidt, Dennis;Stein, Charles Michael;Morrow, Jason D.;Salomon, Ronald M.
Oxidative stress may play a role in the pathogenesis of depression. We tested the hypothesis that urinary F2 isoprostane, a robust marker of oxidative stress, was increased in patients with depression and associated with symptoms and response to treatment. Urinary F2 isoprostane was compared in 18 patients with depression and 36 age and sex matched control subjects. In patients, we tested the association between oxidative stress, depression questionnaires and antidepressant treatment. Urinary F2 isoprostane excretion was significantly higher in patients with depression than in control subjects. This association remained significant after adjustment for age, sex and BMI. Depression symptom severity scores were not correlated with F2 isoprostane excretion. Nine patients were treated with sertraline or bupropion for eight weeks. Depression severity rating scale scores decreased significantly and F2 isoprostane excretion increased. The increase in F2 isoprostane excretion was inversely correlated with the improvement in Hamilton Depression Rating 17 items. In conclusion, oxidative stress is increased in patients with depression. However, although treatment with either bupropion or sertraline reduces the symptoms of depression, it may increase F2 isoprostane excretion. These results suggest that alternative mechanisms, beyond oxidative stress, may be involved in the development of depression and subsequent responses to treatment.
登录
查看更多内容
影响因子：
1.7
作者：
Sarandol, Asli;Sarandol, Emre;Kirli, Selcuk
通讯作者：
Kirli, Selcuk
影响因子：
2.6
作者：
Avalos, I.;Chung, C. P.;Stein, C. M.
通讯作者：
Stein, C. M.
影响因子：
3.5
作者：
Rosa Bautista-Ferrufino, Maria;Cordero, Mario D.;de Miguel, Manuel
通讯作者：
de Miguel, Manuel
影响因子：
11.3
作者：
Teyssier, Jean-Raymond;Ragot, Sylviane;Bonin, Bernard
通讯作者：
Bonin, Bernard
影响因子：
6.6
作者：
Bilici, M;Efe, H;Deger, O
通讯作者：
Deger, O