Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors.
Intraflagellar transport and the sensory outer segment of vertebrate photoreceptors.
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DOI：
10.1002/dvdy.21554
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发表时间：
2008-08
影响因子：
2.5
通讯作者：
Besharse, Joseph C.
中科院分区：
文献类型：
--
作者：
Insinna, Christine;Besharse, Joseph C.
对脊椎动物视杆细胞和视锥细胞光感受器其他部分的分析，为视觉色素吸收的光如何导致调节神经递质释放的膜极性变化提供了丰富的分子理解。这些事件是由大量富集于外节的光转导蛋白来执行的。然而，光转导蛋白被隔离在外段的机制尚不清楚。最近的研究结果表明，外节由感觉纤毛的质膜产生，而鞭毛内运输（IFT）对于许多类型的纤毛和鞭毛的组装至关重要，并且发挥着至关重要的作用，这一发现使人们对这些机制有了深入的了解。在这里，我们回顾了外节组件的一般特征，这些特征可能是大多数感觉纤毛所共有的，也可能是外节所独有的。这些特征说明了对光感受器 IFT 的进一步分析如何可以深入了解 IFT 货物和替代 IFT 驱动蛋白的作用。发展动力学 237：1982–1992，2008。© 2008 Wiley‐Liss, Inc.
Analysis of the other segments of rod and cone photoreceptors in vertebrates has provided a rich molecular understanding of how light absorbed by a visual pigment can result in changes in membrane polarity that regulate neurotransmitter release. These events are carried out by a large group of phototransduction proteins that are enriched in the outer segment. However, the mechanisms by which phototransduction proteins are sequestered in the outer segment are not well defined. Insight into those mechanisms has recently emerged from the findings that outer segments arise from the plasma membrane of a sensory cilium, and that intraflagellar transport (IFT), which is necessary for assembly of many types of cilia and flagella, plays a crucial role. Here we review the general features of outer segment assembly that may be common to most sensory cilia as well those that may be unique to the outer segment. Those features illustrate how further analysis of photoreceptor IFT may provide insight into both IFT cargo and the role of alternative IFT kinesins. Developmental Dynamics 237:1982–1992, 2008. © 2008 Wiley‐Liss, Inc.
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影响因子：
4.6
作者：
Bae, Young-Kyung;Qin, Hongmin;Barr, Maureen M.
通讯作者：
Barr, Maureen M.
影响因子：
13.6
作者：
Fliegauf, Manfred;Horvath, Judit;Omran, Heymut
通讯作者：
Omran, Heymut
IFT驱动素的功能调节扩展了秀丽隐杆线虫中纤毛神经元的感觉曲目。
影响因子：
7.8
作者：
Evans, JE;Snow, JJ;Gunnarson, AL;Ou, GS;Stahlberg, H;McDonald, KL;Scholey, JM
通讯作者：
Scholey, JM
影响因子：
1.8
作者：
Giessl, Andreas;Trojan, Philipp;Wolfrum, Uwe
通讯作者：
Wolfrum, Uwe
DOI：
10.1083/jcb.141.4.993
发表时间：
1998-05-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cole DG;Diener DR;Himelblau AL;Beech PL;Fuster JC;Rosenbaum JL
通讯作者：
Rosenbaum JL