Pain as a stressor: effects of prior nociceptive stimulation on escape responding of rats to thermal stimulation.
Pain as a stressor: effects of prior nociceptive stimulation on escape responding of rats to thermal stimulation.
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DOI：
10.1016/j.ejpain.2009.01.009
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Yezierski RP
中科院分区：
文献类型：
--
作者：
Vierck CJ;Green M;Yezierski RP
在我们之前的研究中，心理压力增强了雄性和雌性大鼠的操作性逃避反应。产生痛觉过敏的压力源是身体束缚和社交失败。压力的另一个来源是疼痛，但尚未使用压力范式记录伤害性刺激对实验动物疼痛敏感性的影响。对伤害性刺激的反射反应会因远程部位的并发刺激而减弱（称为弥散性伤害性抑制控制）。然而，评估实验动物压力的常用方法是测试压力源终止后的效果。因此，在涉及伤害性热刺激的两次连续试验中评估了雄性和雌性大鼠的操作性逃避表现。目的是确定第一次试验中的伤害敏感性和第二次试验中疼痛引起的应激期间的伤害敏感性是否不同。与第一次 44.5°C 刺激试验相比，第二次 44.5°C 刺激试验（之前是 10°C 逃避试验）期间逃避反应增强。同样，在可逃避的 44.5°C 刺激之前，逃避寒冷 (10°C) 的能力也会增强。因此，伤害性刺激增强了随后对热刺激的逃避，表明疼痛促进了疼痛。相比之下，先前的伤害性刺激后出现相反的反射抑制。 10°C 逃避试验后，对 44.5°C 的反射反应降低，44.5°C 逃避试验后，对 10°C 的反射反应降低。
In our previous studies, psychological stress enhanced operant escape responding of male and female rats. The stressors that produced hyperalgesia were physical restraint and social defeat. Another source of stress is pain, but effects of nociceptive stimulation on pain sensitivity of laboratory animals have not been documented using a stress paradigm. Reflex responses to nociceptive stimulation are reduced by concurrent stimulation at a remote site (termed diffuse noxious inhibitory control). However, the usual method of evaluating stress in laboratory animals is to test for effects after termination of the stressor. Accordingly, operant escape performance of male and female rats was evaluated during two successive trials involving nociceptive thermal stimulation. The intent was to determine whether nociceptive sensitivity differed on first trials and during pain-induced stress on second trials. Compared to a first trial of 44.5°C stimulation, escape responding increased during a second trial of 44.5°C stimulation (preceded by an escape trial of 10°C). Similarly, escape from cold (10°C) was enhanced when preceded by escapable 44.5°C stimulation. Thus, nociceptive stimulation enhanced subsequent escape from thermal stimulation, demonstrating facilitation of pain by pain. In contrast, an opposite profile of reflex suppression followed prior nociceptive stimulation. Reflex responses to 44.5°C were decreased following a 10°C escape trial, and reflex responses to 10°C were decreased following a 44.5°C escape trial .
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影响因子：
23.4
作者：
Temml, Christian;Wehrberger, Clemens;Madersbacher, Stephan
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.141218998
发表时间：
2001-07-03
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.8
作者：
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通讯作者：
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