An Investigation on Platelet Transport during Thrombus Formation at Micro-Scale Stenosis
An Investigation on Platelet Transport during Thrombus Formation at Micro-Scale Stenosis
复制标题
微尺度狭窄血栓形成过程中血小板转运的研究
作者：
F. Tovar;G. Rosengarten;M. Nasabi;V. Sivan;K. Khoshmanesh;S. Jackson;A. Mitchell;W. Nesbitt
本文报告了对微尺度狭窄下血细胞质量运输的研究，其中局部应变率微梯度触发血小板聚集。使用微流体流聚焦平台，我们研究了在剪切微梯度条件下主要促进血小板聚集的血流。我们证明，位于通道壁处的相对较薄的表面流是剪切梯度条件下形成聚集体的血小板的主要贡献者。此外，我们描述了红细胞流体动力升力在驱动血小板向狭窄壁和正在形成的聚集体表面的增强平流中的作用。我们表明，这种新型微流体平台可以有效地用于研究驱动血小板募集和聚集形成的质量运输现象的作用，并相信这种方法将有助于更好地理解在急性冠脉综合征和缺血性中风等心血管疾病背景下剪切梯度依赖性盘状血小板聚集的机制。
This paper reports on an investigation of mass transport of blood cells at micro-scale stenosis where local strain-rate micro-gradients trigger platelet aggregation. Using a microfluidic flow focusing platform we investigate the blood flow streams that principally contribute to platelet aggregation under shear micro-gradient conditions. We demonstrate that relatively thin surface streams located at the channel wall are the primary contributor of platelets to the developing aggregate under shear gradient conditions. Furthermore we delineate a role for red blood cell hydrodynamic lift forces in driving enhanced advection of platelets to the stenosis wall and surface of developing aggregates. We show that this novel microfluidic platform can be effectively used to study the role of mass transport phenomena driving platelet recruitment and aggregate formation and believe that this approach will lead to a greater understanding of the mechanisms underlying shear-gradient dependent discoid platelet aggregation in the context of cardiovascular diseases such as acute coronary syndromes and ischemic stroke.
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影响因子：
56.9
作者：
Unger, MA;Chou, HP;Quake, SR
通讯作者：
Quake, SR
血细胞壁相互作用在血栓形成和动脉粥样硬化形成中的作用：一项微流变学研究。
影响因子：
1.1
作者：
Karino,T;Goldsmith,HL
通讯作者：
Goldsmith,HL
影响因子：
20.1
作者：
ASAKURA, T;KARINO, T
通讯作者：
KARINO, T
DOI：
10.1161/01.atv.13.12.1806
发表时间：
1993-12
期刊：
Arteriosclerosis and thrombosis : a journal of vascular biology
影响因子：
--
作者：
R. Schoephoerster;Finn Oynes;German Nunez;Monsoor Kapadvanjwala;Mrinal K. Dewanjee
通讯作者：
R. Schoephoerster;Finn Oynes;German Nunez;Monsoor Kapadvanjwala;Mrinal K. Dewanjee
影响因子：
8.6
作者：
Di Carlo D;Edd JF;Humphry KJ;Stone HA;Toner M
通讯作者：
Toner M