Cortical preparatory activity indexes learned motor memories.
Cortical preparatory activity indexes learned motor memories.
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DOI：
10.1038/s41586-021-04329-x
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发表时间：
2022-02
期刊：
影响因子：
64.8
通讯作者：
中科院分区：
文献类型：
--
作者：
大脑学习和执行各种运动行为的非凡能力利用神经群产生各种活动模式的能力。在这里，我们探讨了伴随运动学习的运动皮层准备活动的系统变化。我们训练恒河猴在卷曲力场中学习手臂伸展任务，该力场在某些但不是所有运动方向上引发新的肌肉力量。我们发现，在预测手部力量的神经子空间中，准备活动的变化跟踪了学习到的行为修改，并将现有的活动模式与更新的动作重新关联起来。沿着与力预测子空间正交的神经种群维度，我们发现准备活动在所有运动方向上均匀地移动，包括那些未被学习改变的运动。在一个清洗期间，当旋度场被删除，准备活动逐渐恢复在力预测子空间，但一致的转变持续存在。这些持续的准备活动模式可以保留已学习场的运动记忆，并支持相同卷曲场的加速再学习。当一组不同的旋度场被依次学习时，我们观察到一组相应的场特异性均匀移位，这些移位将神经状态空间中相关的运动记忆分开。这些准备活动的均匀变化的精确几何形状可以用于索引运动记忆，促进广泛的运动曲目的获取，保留和检索。
The brain’s remarkable ability to learn and execute various motor behaviours harnesses the capacity of neural populations to generate a variety of activity patterns. Here we explore systematic changes in preparatory activity in motor cortex that accompany motor learning. We trained rhesus monkeys to learn an arm-reaching task in a curl force field that elicited new muscle forces for some, but not all, movement directions. We found that in a neural subspace predictive of hand forces, changes in preparatory activity tracked the learned behavioural modifications and reassociated existing activity patterns with updated movements. Along a neural population dimension orthogonal to the force-predictive subspace, we discovered that preparatory activity shifted uniformly for all movement directions, including those unaltered by learning. During a washout period when the curl field was removed, preparatory activity gradually reverted in the force-predictive subspace, but the uniform shift persisted. These persistent preparatory activity patterns may retain a motor memory of the learned field and support accelerated relearning of the same curl field. When a set of distinct curl fields was learned in sequence, we observed a corresponding set of field-specific uniform shifts which separated the associated motor memories in the neural state space. The precise geometry of these uniform shifts in preparatory activity could serve to index motor memories, facilitating the acquisition, retention and retrieval of a broad motor repertoire.
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影响因子：
9.2
作者：
Hwang, Eun Jung;Bailey, Paul M.;Andersen, Richard A.
通讯作者：
Andersen, Richard A.
影响因子：
4.3
作者：
Even-Chen, Nir;Sheffer, Blue;Shenoy, Krishna V.
通讯作者：
Shenoy, Krishna V.
DOI：
10.1073/pnas.0808113105
发表时间：
2008-12-09
影响因子：
11.1
作者：
Jarosiewicz, Beata;Chase, Steven M.;Schwartz, Andrew B.
通讯作者：
Schwartz, Andrew B.
影响因子：
4.6
作者：
Heald JB;Franklin DW;Wolpert DM
通讯作者：
Wolpert DM
影响因子：
2.5
作者：
Howard, Ian S.;Wolpert, Daniel M.;Franklin, David W.
通讯作者：
Franklin, David W.