Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing.
Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing.
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DOI：
10.1038/s41536-023-00313-3
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发表时间：
2023-07-08
影响因子：
7.2
通讯作者：
Guan, Jianjun
中科院分区：
文献类型：
--
作者：
Niu, Hong;Guan, Ya;Zhong, Ting;Ma, Liang;Zayed, Mohamed;Guan, Jianjun
各种疗法已被用于治疗糖尿病伤口，但目前的方案不能同时解决伤口愈合缓慢的关键内在原因，即，异常的皮肤细胞功能（特别是迁移）、延迟的血管生成和慢性炎症。为了解决这一临床差距，我们开发了一种伤口敷料，其中含有基于肽的TGFβ受体II抑制剂（PTβ R2 I）和热敏性和活性氧（ROS）清除水凝胶。伤口敷料在给药后可在糖尿病伤口上快速固化。释放的PTβ R2 I抑制TGFβ1/p38通路，从而改善细胞迁移和血管生成，并减少炎症。同时，PTβ R2 I不干扰调节肌成纤维细胞（伤口愈合的关键细胞类型）所需的TGFβ1/Smad 2/3通路。水凝胶在糖尿病伤口中抑制ROS的能力进一步减少炎症。伤口敷料的单剂量应用显著加速伤口愈合，14天后伤口完全闭合。总之，使用能够适应性调节TGFβ通路的伤口敷料为糖尿病伤口治疗提供了一种新策略。
Various therapies have been utilized for treating diabetic wounds, yet current regiments do not simultaneously address the key intrinsic causes of slow wound healing, i.e., abnormal skin cell functions (particularly migration), delayed angiogenesis, and chronic inflammation. To address this clinical gap, we develop a wound dressing that contains a peptide-based TGFβ receptor II inhibitor (PTβR2I), and a thermosensitive and reactive oxygen species (ROS)-scavenging hydrogel. The wound dressing can quickly solidify on the diabetic wounds following administration. The released PTβR2I inhibits the TGFβ1/p38 pathway, leading to improved cell migration and angiogenesis, and decreased inflammation. Meanwhile, the PTβR2I does not interfere with the TGFβ1/Smad2/3 pathway that is required to regulate myofibroblasts, a critical cell type for wound healing. The hydrogel’s ability to scavenge ROS in diabetic wounds further decreases inflammation. Single-dose application of the wound dressing significantly accelerates wound healing with complete wound closure after 14 days. Overall, using wound dressings capable of adaptively modulating TGFβ pathways provides a new strategy for diabetic wound treatment.
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影响因子：
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作者：
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