Elastomeric electrospun polyurethane scaffolds: the interrelationship between fabrication conditions, fiber topology, and mechanical properties.
Elastomeric electrospun polyurethane scaffolds: the interrelationship between fabrication conditions, fiber topology, and mechanical properties.
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DOI：
10.1002/adma.201003210
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发表时间：
2011-01-04
影响因子：
29.4
通讯作者：
Sacks, Michael S.
中科院分区：
文献类型：
--
作者：
Amoroso, Nicholas J.;D'Amore, Antonio;Hong, Yi;Wagner, William R.;Sacks, Michael S.
静电纺丝由于其能够产生纳米到微米尺度的纤维片，在工程化组织支架的制造中越来越受欢迎。许多研究人员试图对该过程应用不同程度的控制，以生产具有更可预测图案的纤维网。这些尝试在很大程度上局限于控制光纤对准，并分为两类：通过使用快速旋转的心轴[1-3]将光纤拉成对准的光纤物理操纵或在制造过程中操纵电场。[4，5]为了完全量化天然组织和工程化纤维支架的结构，最近开发了一种新的图像分析技术[6]来量化纤维交叉点（数量，位置和密度），连接分布和纤维角度分布（图1b）。这种技术与新的制造方法和全面的机械表征相结合，以促进我们对纤维网络拓扑结构如何影响静电纺丝支架的介观机械性能的理解。具体而言，利用两种先前未评估的制造模式来诱导纤维网络拓扑结构的受控改变：（1）收集芯轴平移速度的变化，以及（2）
Electrospinning has been gaining increasing popularity in the fabrication of engineered tissue scaffolds due to its ability to produce nano to micro scale fibrous sheets. Many investigators have attempted to apply various degrees of control to this process in order to produce fiber meshes with more predictable patterns. These attempts have largely been limited to controlling fiber alignment and have fallen into two categories: physical manipulation of the fibers by pulling them into alignment using a rapidly spinning mandrel [1–3] or manipulation of the electric field during fabrication.[4, 5]To fully quantify the structure of native tissues and engineered fibrous scaffolds, a novel image analysis technique [6] was recently developed to quantify fiber intersections (number, position and density), connectivity distribution, and fiber angle distribution (Fig 1b). This technique was utilized in conjunction with novel fabrication methods and comprehensive mechanical characterization to advance our understanding of how fiber network topology affects meso-scale mechanical properties of electrospun scaffolds. Specifically, two previously unevaluated fabrication modalities were utilized to induce controlled alterations in fiber network topology:(1) variation of collecting mandrel translation velocity, and (2)
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影响因子：
14
作者：
D'Amore A;Stella JA;Wagner WR;Sacks MS
通讯作者：
Sacks MS
影响因子：
14
作者：
Hashizume, Ryotaro;Fujimoto, Kazuro L.;Hong, Yi;Amoroso, Nicholas J.;Tobita, Kimimasa;Miki, Toshio;Keller, Bradley B.;Sacks, Michael S.;Wagner, William R.
通讯作者：
Wagner, William R.
DOI：
10.1002/jbm.10204
发表时间：
2002-09-05
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Guan, JJ;Sacks, MS;Wagner, WR
通讯作者：
Wagner, WR
影响因子：
15
作者：
Kakade, Meghana V.;Givens, Steven;Rabolt, John F.
通讯作者：
Rabolt, John F.
DOI：
10.1163/156856206778366022
发表时间：
2006-01-01
影响因子：
3.6
作者：
Thomas, Vinoy;Jose, Moncy V.;Vohra, Yogesh K.
通讯作者：
Vohra, Yogesh K.