Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.
Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.
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DOI：
10.3389/fphys.2012.00189
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发表时间：
2012
影响因子：
4
通讯作者：
Turner AJ
中科院分区：
文献类型：
--
作者：
Hicks DA;Nalivaeva NN;Turner AJ
脂筏是膜结构域，比本体膜更有序，富含胆固醇和鞘脂。它们代表了蛋白质-脂质和蛋白质-蛋白质相互作用以及细胞信号传导事件的平台。除了它们的正常功能，包括膜运输，配体结合（包括病毒），轴突发育和突触完整性的维持外，筏还涉及包括阿尔茨海默病（AD）在内的几种神经退行性疾病的发病机制。脂筏促进淀粉样前体蛋白（APP）与负责产生淀粉样β肽A β的分泌酶（BACE-1）的相互作用。筏还调节胆碱能信号以及乙酰胆碱酯酶和A β相互作用。此外，胆固醇和GM 1神经节苷脂等主要脂筏成分直接参与了疾病的发病机制。脂质筏完整性的扰动也可以影响导致细胞死亡和AD的各种信号传导途径。在这篇综述中，我们讨论了脂筏及其组分对APP裂解的调节，同时也研究了脂筏在信号事件中的作用。
Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in cholesterol and sphingolipids. They represent a platform for protein-lipid and protein–protein interactions and for cellular signaling events. In addition to their normal functions, including membrane trafficking, ligand binding (including viruses), axonal development and maintenance of synaptic integrity, rafts have also been implicated in the pathogenesis of several neurodegenerative diseases including Alzheimer’s disease (AD). Lipid rafts promote interaction of the amyloid precursor protein (APP) with the secretase (BACE-1) responsible for generation of the amyloid β peptide, Aβ. Rafts also regulate cholinergic signaling as well as acetylcholinesterase and Aβ interaction. In addition, such major lipid raft components as cholesterol and GM1 ganglioside have been directly implicated in pathogenesis of the disease. Perturbation of lipid raft integrity can also affect various signaling pathways leading to cellular death and AD. In this review, we discuss modulation of APP cleavage by lipid rafts and their components, while also looking at more recent findings on the role of lipid rafts in signaling events.
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影响因子：
2.5
作者：
ATACK, JR;PERRY, EK;FAIRBAIRN, A
通讯作者：
FAIRBAIRN, A
影响因子：
4.8
作者：
Arcaro, Alexandre;Aubert, Muriel;Seckl, Michael J.
通讯作者：
Seckl, Michael J.
DOI：
10.1016/s0006-291x(05)81412-3
发表时间：
1991-11-27
影响因子：
3.1
作者：
ARAKI, W;KITAGUCHI, N;KIMURA, J
通讯作者：
KIMURA, J
影响因子：
4.4
作者：
Arduise, Cecile;Abache, Toufik;Le Naour, Francoise
通讯作者：
Le Naour, Francoise
DOI：
10.2741/buxbaum
发表时间：
2002-04-01
期刊：
FRONTIERS IN BIOSCIENCE
影响因子：
--
作者：
Buxbaum, JD;Cullen, EI;Friedhoff, LT
通讯作者：
Friedhoff, LT